WO2025133694 - FCRN/HSA-BINDING MOLECULES AND METHODS OF USE

National phase entry is expected:
Publication Number WO/2025/133694
Publication Date 26.06.2025
International Application No. PCT/IB2024/000718
International Filing Date 20.12.2024
Title **
[English] FCRN/HSA-BINDING MOLECULES AND METHODS OF USE
[French] MOLÉCULES DE LIAISON À FCRN/HSA ET PROCÉDÉS D'UTILISATION
Applicants **
ARGENX BV
Inventors
BOBKOV, Vladimir
SILENCE, Karen
VAN SANTBERGEN, Jolien
BIGIRIMANA, René
DE HAARD, Johannes
BLANCHETOT, Christophe
Priority Data
63/612,866   20.12.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4499
EPO Filing, Examination, Granting62820
Japan Filing, Examination, Granting4066
South Korea Filing, Examination, Granting5950
USA Filing, Examination, Granting20790
MasterCard Visa
Total: 98,125

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] Provided herein are binding molecules comprising a human neonatal Fc receptor (FcRn) binding molecule and at least one HSA-binding domain linked to the FcRn-binding molecule. Polynucleotides, vectors, host cells, and methods of production are also provided herein. Methods of treating an antibody-mediated disorder with an FcRn/HSA-binding molecule are further provided.[French] L'invention concerne des molécules de liaison comprenant une molécule de liaison au récepteur Fc néonatal humain (FcRn) et au moins un domaine de liaison HSA lié à la molécule de liaison au FcRn. L'invention concerne également des polynucléotides, des vecteurs, des cellules hôtes et des procédés de production. L'invention concerne en outre des méthodes de traitement d'un trouble médié par anticorps avec une molécule de liaison à FcRn/HSA.