WO2025068766 - COMPOSITIONS AND METHODS TO MODULATE IDIOPATHIC PULMONARY FIBROTIC ASSOCIATED LONG NONCODING RNAS

National phase entry:
Publication Number WO/2025/068766
Publication Date 03.04.2025
International Application No. PCT/IB2024/000524
International Filing Date 24.09.2024
Title **
[English] COMPOSITIONS AND METHODS TO MODULATE IDIOPATHIC PULMONARY FIBROTIC ASSOCIATED LONG NONCODING RNAS
[French] COMPOSITIONS ET PROCÉDÉS POUR MODULER DES ARN LONGS NON CODANTS ASSOCIÉS À LA FIBROSE PULMONAIRE IDIOPATHIQUE
Applicants **
HAYA THERAPEUTICS SA
Inventors
LYNN, Heather, D.
MICHELETTI, Rudi
OUNZAIN, Samir
MINA, Marco
BLESSING, Daniel, Roman
Priority Data
63/540,328   25.09.2023   US
63/616,204   29.12.2023   US
63/648,458   16.05.2024   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting6801
EPO Filing, Examination, Granting34283
Japan Filing, Examination, Granting3048
South Korea Filing, Examination, Granting3948
USA Filing, Examination, Granting13890
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Total: 61,970

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Abstract[English] Disclosed herein are modulators of a long non-coding RNA (IncRNA), wherein an expression of the IncRNA is associated with idiopathic pulmonary fibrosis. Further provided herein are methods of treating idiopathic pulmonary fibrosis a subject in need thereof. Also, provided herein are methods of predicting severity and progression of idiopathic pulmonary fibrosis based on expression of the IncRNAs described herein.[French] Sont ici divulgués des modulateurs d'un ARN long non codant (ARNInc), une expression de l'ARNInc étant associée à la fibrose pulmonaire idiopathique. Sont en outre ici divulguées des méthodes de traitement de la fibrose pulmonaire idiopathique chez un sujet en ayant besoin. Sont également ici divulgués des procédés de prédiction de la gravité et de la progression de la fibrose pulmonaire idiopathique sur la base de l'expression des ARNInc ici décrits.