WO2024256870 - SMALL MOLECULE LIGANDS AND APTAMERS
National phase entry:
Publication Number
WO/2024/256870
Publication Date
19.12.2024
International Application No.
PCT/IB2024/000314
International Filing Date
14.06.2024
Title **
[English]
SMALL MOLECULE LIGANDS AND APTAMERS
[French]
LIGANDS ET APTAMÈRES À PETITES MOLÉCULES
Applicants **
MEIRAGTX GENE REGULATION LIMITED
92 Britannia Walk
London N1 7NQ, GB
Inventors
LIU, Kevin, G.
c/o MeiraGTx
450 East 29th Street
14th Street
New York, NY 10016, US
KIM, Ji-In
c/o MeiraGTx
450 East 29th Street
14th Street
New York, NY 10016, US
GUO, Xuecui
c/o MeiraGTx
450 East 29th Street
14th Street
New York, NY 10016, US
FORBES, Alexandria
c/o MeiraGTx
450 East 29th Street
14th Street
New York, NY 10016, US
Priority Data
63/508,204
14.06.2023
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2351 | |
| EPO | Filing, Examination | 8031 | |
| Japan | Filing | 593 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 4060 |
Total: 15610 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides small molecules of Formula (I) that bind to aptamers. Also contemplated are riboswitches and polynucleotide cassettes for regulating the expression of a target gene in response to the small molecule, wherein the polynucleotide cassettes comprise the aptamers disclosed herein. The small molecules disclosed herein that bind to the aptamers disclosed herein are modulators of target gene expression where the target gene contains a riboswitch comprising an aptamer described herein.[French]
La présente invention concerne de petites molécules de formule (I) qui se lient à des aptamères. L'invention concerne également des ribocommutateurs et des cassettes polynucléotidiques pour réguler l'expression d'un gène cible en réponse à la petite molécule, les cassettes polynucléotidiques comprenant les aptamères selon l'invention. Les petites molécules divulguées qui se lient aux aptamères selon l'invention sont des modulateurs de l'expression génique cible où le gène cible contient un riborégulateur comprenant un aptamère selon l'invention.