Publication Number
WO/2024/175997
Publication Date
29.08.2024
International Application No.
PCT/IB2024/000091
International Filing Date
20.02.2024
Title
[English]
WATER-SOLUBLE CHLOROPHYLL PROTEIN AS EFFICIENT PHOTOSENSITIZER FOR CANCER PHOTODYNAMIC THERAPY
[French]
PROTÉINE WSCP (WATER-SOLUBLE CHLOROPHYLL PROTEIN) EN TANT QUE PHOTOSENSIBILISATEUR EFFICACE POUR UNE THÉRAPIE PHOTODYNAMIQUE DU CANCER
Applicants **
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Clear Water Bay, Kowloon
Hong Kong, CN
Inventors **
TONG, Rongbiao
c/o The Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong, CN
SUN, Fei
c/o The Hong Kong University of Science and Technology
Clear Water Bay, Kowloon
Hong Kong, CN
LIANG, Lixin
c/o Guangxi University
Nanning, Guangxi 530004, CN
WANG, Wenjun
c/o Institute of Molecular Physiology
Shenzhen Bay Laboratory
Shenzhen, 518036, CN
XU, Yingjie
40-202, Xinxing Village
Meiling Street, Futian District
Shenzhen, CN
Priority Data
63/485,928
20.02.2023
US
Application details
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Abstract
[English]
The subject invention pertains to a safe and effective photosensitizer that expands the clinical use of photodynamic therapy (PDT) as a non-invasive cancer treatment. Specifically, the subject invention provides methods of using water-soluble chlorophyll protein (WSCP) as a new photosensitizer for cancer phototherapy. Advantageously, WSCP is stable, non-toxic, and biocompatible while generating reactive oxygen species, making it useful for deep-tissue PDT.
[French]
La présente invention concerne un photosensibilisateur sûr et efficace qui étend l'utilisation clinique d'une thérapie photodynamique (PDT) en tant que traitement anticancéreux non invasif. Spécifiquement, la présente invention concerne des procédés d'utilisation de la protéine WSCP (water-soluble chlorophyll protein) en tant que nouveau photosensibilisateur pour la photothérapie du cancer. De manière avantageuse, la protéine WSCP est stable, non toxique et biocompatible tout en générant des espèces réactives de l'oxygène, ce qui la rend utile pour la PDT dans les tissus profonds.