WO2024147060 - NOVEL IONIZABLE LIPID COMPOUNDS FOR NUCLEIC ACID DELIVERY

National phase entry:
Publication Number WO/2024/147060
Publication Date 11.07.2024
International Application No. PCT/IB2023/063252
International Filing Date 26.12.2023
Title **
[English] NOVEL IONIZABLE LIPID COMPOUNDS FOR NUCLEIC ACID DELIVERY
[French] NOUVEAUX COMPOSÉS LIPIDIQUES IONISABLES POUR ADMINISTRATION D'ACIDES NUCLÉIQUES
Applicants **
CELON PHARMA S.A. Ogrodowa 2A 05-092 Kielpin/Lomianki, PL
Inventors
WIECZOREK, Maciej Majowa 20 05-092 Lomianki, PL
MROCZKIEWICZ, Michal Powazkowska 42/264 01-797 Warszawa, PL
MACH, Mateusz Lakocinska 22/9 03-320 Warszawa, PL
DUBIEL, Krzysztof Kameralna 76/2 05-082 Babice Nowe, PL
LEMEK, Tadeusz Bratyslawska 2/C61 31-201 Krakow, PL
SETNER, Bartosz Drzewieckiego 15/9 54-129 Wroclaw, PL
JUSZCZYK, Ewelina Ordona 12B/10 01-237 Warszawa, PL
ZERO, Pawel Muszlowa 2/6 01-357 Warsaw, PL
GALAZKA, Kinga Kasprzaka 31 B/222 01-234 Warszawa, PL
MAREK, Gabriela Dzieci Warszawy 17 D/98 02-495 Warszawa, PL
PIĄTKOWSKI, Jakub 3-go Maja 26 13-230 Lidzbark, PL
Priority Data
63/478,560   05.01.2023   US
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Quotation for National Phase entry

Country StagesTotal
China Filing3110
EPO Filing, Examination15371
Japan Filing586
South Korea Filing574
USA Filing, Examination12460
MasterCard Visa

Total: 32101

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] Novel ionizable lipid compounds, compositions comprising such ionizable lipid compounds, and related methods of their use are disclosed. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including biologically active agents, such as siRNA or mRNA, are useful in the delivery of said biologically active agents to subjects in need thereof.[French] L'invention concerne de nouveaux composés lipidiques ionisables, des compositions comprenant de tels composés lipidiques ionisables, et leurs procédés d'utilisation associés. Les compositions de nanoparticules comprennent un nouveau lipide, ainsi que des lipides supplémentaires tels que des phospholipides, des lipides structuraux, et des lipides PEG. Les compositions de nanoparticules comprenant en outre des agents biologiquement actifs, tels que l'ARNsi ou l'ARNm, sont utiles dans l'administration desdits agents biologiquement actifs à des sujets en ayant besoin.
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