WO2024141907 - METHODS FOR DIAGNOSING OR MONITORING A DISEASE IN A SUBJECT USING SPECTROSCOPY
National phase entry:
Publication Number
WO/2024/141907
Publication Date
04.07.2024
International Application No.
PCT/IB2023/063176
International Filing Date
22.12.2023
Title **
[English]
METHODS FOR DIAGNOSING OR MONITORING A DISEASE IN A SUBJECT USING SPECTROSCOPY
[French]
MÉTHODES DE DIAGNOSTIC OU DE SURVEILLANCE D'UNE MALADIE CHEZ UN SUJET À L'AIDE D'UNE SPECTROSCOPIE
Applicants **
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
KING SAUD UNIVERSITY
Inventors
INCITTI, Roberto
GOJOBORI, Takashi
LIBERALE, Carlo
NABHOLTZ, Jean-Marc Andre
AL-SALEH, Khalid
GRASSI, Elisa
BAHADOOR, Mohun R.K.
Priority Data
63/435,371
27.12.2022
US
Application details
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International Searching Authority |
MOIP
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2991 | |
| EPO | Filing, Examination, Granting | 23604 | |
| Japan | Filing, Examination, Granting | 2833 | |
| South Korea | Filing, Examination, Granting | 2578 | |
| USA | Filing, Examination, Granting | 8140 |
Total:
40,146
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
A method for diagnosing a disease, such as breast cancer, in a biological sample using spectroscopic data is described. The method involves a computer-implemented method that converts spectroscopic vibrational from the sample into a profile and scores the profile using a pair of reference profiles. Based on the score and a threshold, it can be determined whether the subject from which the sample was obtained has a disease, and, if so, to what extent. The method also allows detection of early and pre-disease states in subjects based on the detection of the signal of low concentration analytes that are indicative of early or incipient disease states. The method is non-invasive, non-subjective, highly specific, and sensitive. The method affords the application of a single standard of diagnostic accuracy, independent of the availability of expert pathologists.[French]
La présente invention concerne une méthode de diagnostic d'une maladie telle que le cancer du sein, dans un échantillon biologique à l'aide de données spectroscopiques. La méthode comprend un procédé mis en œuvre par ordinateur qui convertit une vibration spectroscopique de l'échantillon en un profil et note le profil à l'aide d'une paire de profils de référence. Sur la base du score et d'un seuil, il est possible de déterminer si le sujet sur qui a été prélevé l'échantillon souffre d'une maladie, et, si tel est le cas, la gravité de la maladie. La méthode permet également la détection d'états précoces et pré-pathologiques sur la base de la détection d'un signal d'analytes à faible concentration qui sont révélateurs d'un état pathologique précoce ou primaire. La méthode est non invasive, non subjective, hautement précise et sensible. La méthode permet l'application d'un seul critère de précision diagnostique, indépendamment de la disponibilité d'experts pathologistes.