WO2024110803 - POLYMERIC COMPOUNDS COMPRISING ANTINEOPLASTIC AGENTS

National phase entry:
Publication Number WO/2024/110803
Publication Date 30.05.2024
International Application No. PCT/IB2023/061127
International Filing Date 03.11.2023
Title **
[English] POLYMERIC COMPOUNDS COMPRISING ANTINEOPLASTIC AGENTS
[French] COMPOSÉS POLYMÈRES COMPRENANT DES AGENTS ANTINÉOPLASIQUES
Applicants **
SONY GROUP CORPORATION
Inventors
MATRAY, Tracy
VANBRUNT, Michael
MCCUTCHEON, John Michael
Priority Data
63/384,712   22.11.2022   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4227
EPO Filing, Examination, Granting56103
Japan Filing, Examination, Granting3961
South Korea Filing, Examination, Granting5438
USA Filing, Examination, Granting17990
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Total: 87,719

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Abstract[English] A water soluble polymeric compound is disclosed. The compound comprises: i) one or more antineoplastic agents; ii) a heteroalkylene backbone comprising negatively charged groups at physiological pH; iii) one or more linear or branched linkers comprising a self-immolative group and an optional spacer group, the linker linking each antineoplastic agent to the heteroalkylene backbone; and iv) a reactive group capable of forming a covalent bond to a targeting moiety. The water soluble polymeric compound finds utility in a number of applications, including use as therapeutic agents for various treatment methods.[French] Un composé polymère soluble dans l'eau est divulgué. Le composé comprend : i) un ou plusieurs agents antinéoplasiques ; ii) un squelette hétéroalkylène comprenant des groupes chargés négativement à un pH physiologique ; iii) un ou plusieurs lieurs linéaires ou ramifiés comprenant un groupe auto-immolable et un groupe espaceur facultatif, le lieur liant chaque agent antinéoplasique au squelette hétéroalkylène ; et iv) un groupe réactif permettant de former une liaison covalente à une fraction de ciblage. Le composé polymère soluble dans l'eau trouve une utilité dans un certain nombre d'applications, comprenant l'utilisation en tant qu'agents thérapeutiques pour divers procédés de traitement.

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