WO2024084440 - NUCLEIC ACID ENRICHMENT AND DETECTION
National phase entry:
Publication Number
WO/2024/084440
Publication Date
25.04.2024
International Application No.
PCT/IB2023/060588
International Filing Date
19.10.2023
Title **
[English]
NUCLEIC ACID ENRICHMENT AND DETECTION
[French]
ENRICHISSEMENT ET DÉTECTION D'ACIDE NUCLÉIQUE
Applicants **
BIOFIDELITY LTD
Inventors
OSBORNE, Robert
STOLAREK-JANUSZKIEWICZ, Magdalena
BALMFORTH, Barnaby
Priority Data
63/380,105
19.10.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2614 | |
| EPO | Filing, Examination, Granting | 17719 | |
| Japan | Filing, Examination, Granting | 2745 | |
| South Korea | Filing, Examination, Granting | 3099 | |
| USA | Filing, Examination, Granting | 7340 |
Total:
33,517
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided herein are systems and methods for the enrichment and detection of nucleic acid molecules. In particular, provided herein are systems and methods for the selective enrichment of a desired nucleic acid molecule in a sample containing non-desired nucleic acid molecules in which a probe with different complementarity to the the desired compared to the undesired nucleic acid, e.g. wild-type and variant. The probe may be bound to the solid phase, e.g. via biotin, the probe binding to the undesired may be cleaved so that the undesired is released and the desired nucleic acid is enriched by binding to the solid phase. The method may also employ differential release from the probe.[French]
L'invention concerne des systèmes et des procédés pour l'enrichissement et la détection de molécules d'acide nucléique. En particulier, l'invention concerne des systèmes et des procédés pour l'enrichissement sélectif d'une molécule d'acide nucléique souhaitée dans un échantillon contenant des molécules d'acide nucléique non souhaitées, une sonde ayant une complémentarité différente avec l'acide nucléique souhaité en comparaison avec l'acide nucléique non souhaité, par exemple de type sauvage et variant. La sonde peut être liée à la phase solide, par exemple, par la biotine, la liaison de la sonde à l'acide nucléique non souhaité peut être clivée de manière que l'acide nucléique non souhaité est libéré et l'acide nucléique souhaité est enrichi par liaison à la phase solide. Le procédé peut aussi utiliser une libération différente à partir de la sonde.