WO2023238100 - METHODS FOR PRODUCING ALPHA-CYCLODEXTRINS

National phase entry:
Publication Number WO/2023/238100
Publication Date 14.12.2023
International Application No. PCT/IB2023/055978
International Filing Date 09.06.2023
Title **
[English] METHODS FOR PRODUCING ALPHA-CYCLODEXTRINS
[French] PROCÉDÉS DE PRODUCTION D'ALPHA-CYCLODEXTRINES
Applicants **
BEREN THERAPEUTICS P.B.C. 9200 Sunset Blvd Ste 1010 West Hollywood, California 90069, US
Inventors
GROBAN, Eli 587 15th Avenue San Francisco, California 94118, US
HU, Karl 2nd Fl, Building F, 1 North Guotai Rd Economic Development Zone Zhangjiagang, Jiangsu 215600, CN
PFEIFFER, Steven c/o Beren Therapeutics P.B.C. 9200 Sunset Boulevard Suite 1010 West Hollywood, CA 90069, US
RIZKIN, Benjamin c/o Beren Therapeutics P.B.C. 9200 Sunset Boulevard Suite 1010 West Hollywood, CA 90069, US
BENKOVICS, Gabor c/o Beren Therapeutics P.B.C. 9200 Sunset Blvd. Suite 1010 West Hollywood, California 90069, US
Priority Data
PCT/CN2022/098225   10.06.2022   CN
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Quotation for National Phase entry

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EPO Filing, Examination13087
Japan Filing590
South Korea Filing574
USA Filing, Examination6710
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Total: 23,092

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Abstract[English] Provided herein are methods for the enzymatic production of alpha- cyclodextrin from sucrose. The methods involve contacting sucrose with one or more enzymes to convert sucrose to amylose, followed by contacting the amylose with one or more enzymes to convert the amylose to alpha-cyclodextrin. The methods produce higher yields of alpha-cyclodextrin relative to beta-cyclodextrin, gamma-cyclodextrin, or both.[French] L'invention concerne des procédés de production enzymatique d'alpha-cyclodextrine à partir de saccharose. Dans certains cas, les procédés consistent à mettre en contact du saccharose avec une ou plusieurs enzymes pour convertir le saccharose en amylose, puis à mettre en contact l'amylose avec une ou plusieurs enzymes pour convertir l'amylose en alpha-cyclodextrine. Dans certains cas, les procédés produisent des rendements plus élevés d'alpha-cyclodextrine par rapport à la bêta-cyclodextrine, la gamma-cyclodextrine, ou les deux.