WO2023238099 - METHODS FOR PRODUCING BETA-CYCLODEXTRINS

National phase entry:
Publication Number WO/2023/238099
Publication Date 14.12.2023
International Application No. PCT/IB2023/055977
International Filing Date 09.06.2023
Title **
[English] METHODS FOR PRODUCING BETA-CYCLODEXTRINS
[French] PROCÉDÉS DE PRODUCTION DE BÊTA-CYCLODEXTRINES
Applicants **
BEREN THERAPEUTICS P.B.C.
Inventors
GROBAN, Eli
HU, Karl
PFEIFFER, Steven
RIZKIN, Benjamin
BENKOVICS, Gabor
Priority Data
PCT/CN2022/098215   10.06.2022   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting3096
EPO Filing, Examination, Granting20806
Japan Filing, Examination, Granting2838
South Korea Filing, Examination, Granting3279
USA Filing, Examination, Granting8990
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Total: 39,009

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Abstract[English] Provided herein are methods for the enzymatic production of beta-cyclodextrin from sucrose. In some cases, the methods involve contacting sucrose with one or more enzymes to convert sucrose to amylose, followed by contacting the amylose with one or more enzymes to convert the amylose to beta-cyclodextrin. In some cases, the methods produce higher yields of beta-cyclodextrin relative to alpha-cyclodextrin, gamma-cyclodextrin, or both.[French] L'invention concerne des procédés de production enzymatique de bêta-cyclodextrine à partir de saccharose. Dans certains cas, les procédés consistent à mettre en contact du saccharose avec une ou plusieurs enzymes pour convertir le saccharose en amylose, puis à mettre en contact l'amylose avec une ou plusieurs enzymes pour convertir l'amylose en bêta-cyclodextrine. Dans certains cas, les procédés produisent des rendements plus élevés de bêta-cyclodextrine par rapport à l'alpha-cyclodextrine, la gamma-cyclodextrine, ou les deux.

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