WO2023181010 - ANTI-WT1 ANTIGEN-BINDING PROTEINS AND USES THEREOF

National phase entry:
Publication Number WO/2023/181010
Publication Date 28.09.2023
International Application No. PCT/IB2023/052959
International Filing Date 24.03.2023
Title **
[English] ANTI-WT1 ANTIGEN-BINDING PROTEINS AND USES THEREOF
[French] PROTÉINES DE LIAISON À L'ANTIGÈNE ANTI-WT1 ET LEURS UTILISATIONS
Applicants **
UNIVERSITY HEALTH NETWORK
Inventors
HIRANO, Naoto
OCHI, Toshiki
WANG, Chung-Hsi
Priority Data
63/323,459   24.03.2022   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting5843
EPO Filing, Examination, Granting87619
Japan Filing, Examination, Granting4501
South Korea Filing, Examination, Granting7190
USA Filing, Examination, Granting27490
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Total: 132,643

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present disclosure is directed to antigen-binding molecules that specifically bind peptide fragments of tumor antigens, wherein the peptide fragment is capable of being presented by more than one type of major histocompatibility complex (MHC) class II molecule. In some aspects, the tumor antigen is a WT1 polypeptide. Other aspects are directed to antibodies, multispecific antibodies, and chimeric antigen receptors, and nucleotides encoding the same. Other aspects are directed to methods of administering the same to a subject in need thereof.[French] La présente divulgation concerne des molécules de liaison à l'antigène qui se lient de manière spécifique à des fragments peptidiques d'antigènes tumoraux, le fragment peptidique pouvant être présenté par plus d'un type de molécule de complexe majeur d'histocompatibilité (CMH) de classe II. Dans certains aspects, l'antigène tumoral est un polypeptide WT1. D'autres aspects concernent des anticorps, des anticorps multispécifiques, des récepteurs antigéniques chimériques et des nucléotides codant pour ceux-ci. D'autres aspects concernent leurs méthodes d'administration à un sujet en ayant besoin.