WO2023223105 - A PROCESS OF PREPARATION OF 3'-(TRIFLUOROMETHYL)ACETOPHENONE (TFMAP)
National phase entry is expected:
Publication Number
WO/2023/223105
Publication Date
23.11.2023
International Application No.
PCT/IB2023/051349
International Filing Date
15.02.2023
Title **
[English]
A PROCESS OF PREPARATION OF 3'-(TRIFLUOROMETHYL)ACETOPHENONE (TFMAP)
[French]
PROCÉDÉ DE PRÉPARATION DE 3 '- (TRIFLUOROMÉTHYLE) ACÉTOPHÉNONE (TFMAP)
Applicants **
DEEPAK NITRITE LIMITED
Inventors
ISMAILI, Aminmahamad N
PATIL, Vilas
MANSURI, Javedhusen K
Priority Data
202221028493
18.05.2022
IN
Application details
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| Number of Multi-Dependent Claims | * |
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2074 | |
| EPO | Filing, Examination, Granting | 11708 | |
| Japan | Filing, Examination, Granting | 2167 | |
| South Korea | Filing, Examination, Granting | 2005 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,694
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Disclosed is a system (100) and process (300) for preparation of 3'-(Trifluoromethyl) acetophenone (TFMAP), wherein disclosed TFMAP provides appearance ranging from colourless to orange liquid, purity in the range of 99-99.9%, and yield in the range of 60-90%. The process (300) for preparation of the TFMAP include preparation of a diazo solution from reacting 3-aminobenzotrifluoride and sulfuric acid, followed by lot-wise addition of diazo solution with acetaldoxime to obtain 3'- (Trifluoromethyl)acetophenone oxime, which is further treated with 30% HCl solution and undergo distillation to obtain 3'-(Trifluoromethyl) acetophenone having enhanced yield and purity.[French]
Sont divulgués un système (100) et un procédé (300) pour la préparation de 3 '- (trifluorométhyle) acétophénone (TFMAP), le TFMAP divulgué fournissant un aspect allant d'un liquide incolore à orange, une pureté dans la plage de 99 à 99,9 %, et un rendement dans la plage de 60 à 90 %. Le procédé (300) pour la préparation du TFMAP comprend la préparation d'une solution diazo à partir de la réaction de 3-aminobenzotrifluorure et d'acide sulfurique, suivie d'une addition par lots de solution diazo avec de l'acétaldoxime pour obtenir l'oxime de 3 '- (trifluorométhyle) acétophénone, qui est en outre traitée avec une solution HCl à 30 % et subit une distillation pour obtenir de la 3 '- (trifluorométhyle) acétophénone ayant un rendement et une pureté améliorés.