WO2023067515 - THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
National phase entry is expected:
Publication Number
WO/2023/067515
Publication Date
27.04.2023
International Application No.
PCT/IB2022/060050
International Filing Date
19.10.2022
Title **
[English]
THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
[French]
COMPOSÉS THIADIAZOLYLES UTILISÉS COMME INHIBITEURS DE L'ADN POLYMÉRASE THÊTA
Applicants **
IDEAYA BIOSCIENCES, INC.
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED
980 Great West Road
Brentford Middlesex TW89GS, GB
Inventors
WANG, Chenbo
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
JAIPURI, Firoz Ali
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
SEVERANCE, Daniel Lee
8439 Torrell Way
San Francisco, California 92126, US
BECK, Hilary Plake
7000 Shoreline Court
South San Francisco, California 94080, US
JONES, Brian Thomas
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
DUFFY, Kevin J.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
KIESOW, Terence John
c/o 1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
KWON, Doo-Hyun
c/o 1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
BARSANTI, Paul A.
7000 Shoreline Court, Suite 350
South San Francisco, California 94080, US
Priority Data
63/270,772
22.10.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 3711 | |
| EPO | Filing, Examination | 28423 | |
| Japan | Filing | 591 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 16060 |
Total: 49360 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Disclosed herein are certain thiadiazolyl derivatives Formula (I): (I) that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.[French]
L'invention concerne certains dérivés de thiadiazolyle de formule (I) : (I) qui inhibent l'activité de l'ADN polymérase thêta (Polθ), en particulier inhibent l'activité Polθ en inhibant l'activité de domaine hélicase ATP-dépendant de Polθ. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des procédés de traitement et/ou de prévention de maladies pouvant être traitées par inhibition de Polθ, telles que le cancer, notamment les cancers déficients en recombinaison homologue (RH).