WO2023062542 - RECOMBINANT YEAST CELL HAVING INCREASED PYRUVATE DECARBOXYLASE ACTIVITY
National phase entry:
Publication Number
WO/2023/062542
Publication Date
20.04.2023
International Application No.
PCT/IB2022/059754
International Filing Date
11.10.2022
Title **
[English]
RECOMBINANT YEAST CELL HAVING INCREASED PYRUVATE DECARBOXYLASE ACTIVITY
[French]
CELLULE DE LEVURE RECOMBINANTE AYANT UNE ACTIVITÉ PYRUVATE DÉCARBOXYLASE ACCRUE
Applicants **
DANSTAR FERMENT AG
Poststrasse 30
CH-6300 Zug, CH
Inventors
ARGYROS, Aaron
c/o Mascoma LLC
67 Etna Rd #200
Lebanon, New Hampshire 03766, US
VAN DIJKEN, Johannes Pieter
c/o Mascoma LLC
67 Etna Rd., #200
Lebanon, New Hampshire 03766, US
CARIGNAN, Bailey Morgan
c/o Mascoma LLC
67 Etna Rd #200
Lebanon, New Hampshire 03766, US
BARRETT, Trisha
c/o Mascoma LLC
67 Etna Rd #200
Lebanon, New Hampshire 03766, US
STONEHOUSE, Emily
c/o Mascoma LLC
67 Etna Rd., #200
Lebanon, New Hampshire 03766, US
Priority Data
63/254,366
11.10.2021
US
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2638 | |
| EPO | Filing, Examination | 17681 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 8760 |
Total: 30243 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides a recombinant yeast cell for making ethanol. The recombinant yeast cell comprises a first genetic modification to increase an ethanol yield in the recombinant yeast cell when compared to a parental yeast cell. The recombinant yeast cell also comprises a second genetic modification capable of increasing pyruvate decarboxylase activity in the recombinant yeast cell when compared to the parental yeast cell. The parental yeast cell lacks the first genetic modification and the second genetic modification. The present disclosure also provides methods for making the recombinant yeast cell as well processes for using the recombinant yeast cell to make ethanol.[French]
La présente invention concerne une cellule de levure recombinante pour la fabrication d'éthanol. La cellule de levure recombinante comprend une première modification génétique pour augmenter le rendement en éthanol dans la cellule de levure recombinante par comparaison avec une cellule de levure parentale. La cellule de levure recombinante comprend également une seconde modification génétique capable d'augmenter l'activité pyruvate décarboxylase dans la cellule de levure recombinante lorsqu'elle est comparée à la cellule de levure parentale. La cellule de levure parentale est dépourvue de la première modification génétique et de la seconde modification génétique. La présente invention concerne également des procédés de fabrication de la cellule de levure recombinante ainsi que des procédés d'utilisation de la cellule de levure recombinante pour fabriquer de l'éthanol.