WO2023057946 - SERUM HALF-LIFE EXTENDED PD-L1 BINDING POLYPEPTIDES

National phase entry:
Publication Number WO/2023/057946
Publication Date 13.04.2023
International Application No. PCT/IB2022/059548
International Filing Date 06.10.2022
Title **
[English] SERUM HALF-LIFE EXTENDED PD-L1 BINDING POLYPEPTIDES
[French] POLYPEPTIDES SÉRIQUES DE LIAISON PD-L1 PROLONGÉS À DEMI-VIE
Applicants **
AVACTA LIFE SCIENCES LIMITED
Inventors
BASRAN, Amrik
JENKINS, Emma
ADAM, Estelle
STANLEY, Emma
WRITER, Michele
Priority Data
63/253,446   07.10.2021   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting6324
EPO Filing, Examination, Granting52667
Japan Filing, Examination, Granting3712
South Korea Filing, Examination, Granting5473
USA Filing, Examination, Granting18240
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Total: 86,416

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present disclosure provides engineered PD-L1-binding Stefin A polypeptide variants, polynucleotides encoding the engineered PD-L1-binding Stefin A polypeptide variants, cells expressing the polypeptide variants, pharmaceutical preparations of the polypeptide variants, and uses of the polypeptide variants in the treatment of various human conditions, including cancer.[French] La présente divulgation concerne des variants polypeptidiques modifiés de la stéfine A se liant à PD-L1, des polynucléotides codant pour ces variants polypeptidiques modifiés de la stéfine A se liant à PD-L1, des cellules exprimant lesdits variants polypeptidiques, des préparations pharmaceutiques desdits variants polypeptidiques et des utilisations desdits variants polypeptidiques dans le traitement de diverses affections humaines, notamment le cancer.