WO2023037248 - IDENTIFICATION OF CHANGING PATHWAYS OR DISEASE INDICATORS THROUGH CLUSTER ANALYSIS

National phase entry:
Publication Number WO/2023/037248
Publication Date 16.03.2023
International Application No. PCT/IB2022/058384
International Filing Date 06.09.2022
Title **
[English] IDENTIFICATION OF CHANGING PATHWAYS OR DISEASE INDICATORS THROUGH CLUSTER ANALYSIS
[French] IDENTIFICATION DE VOIES DE CHANGEMENT OU D'INDICATEURS DE MALADIE PAR ANALYSE PAR GROUPE
Applicants **
DH TECHNOLOGIES DEVELOPMENT PTE. LTD. 33 Marsiling Industrial Estate Road 3, #04-06 Singapore 739256, SG
Inventors
TATE, Stephen A. 71 Four Valley Drive Concord, Ontario L4K 4V8, CA
Priority Data
63/260,975   08.09.2021   US
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Quotation for National Phase entry

Country StagesTotal
China Filing1296
EPO Filing, Examination5071
Japan Filing590
South Korea Filing575
USA Filing, Examination2710
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Total: 10242

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] dimensions. Two clustering algorithms are applied to the measurements, producing two sets of clusters, and compounds in the sets are identified. Two or more compounds found in a cluster of both sets are identified. The two or more compounds are compared to groups of compounds related to a biological process to identify a group that includes the two or more compounds. An additional compound is selected from the group. The two sets are reanalyzed to identify the compound in the sets. A co-occurrence matrix is calculated that quantifies the co-occurrence of the compound and each of the two or more compounds in the sets. If no co-occurrence quantity for the compound and each of the two or more compounds in the matrix is below a threshold, the two or more compounds are verified.[French] dimensions. Deux algorithmes de regroupement sont appliqués aux mesures, produisant deux ensembles de groupes, et des composés dans les ensembles sont identifiés. Au moins deux composés trouvés dans un groupe des deux ensembles sont identifiés. Les deux, ou plus, composés sont comparés à des groupes de composés liés à un processus biologique pour identifier un groupe qui comprend les deux, ou plus, composés. Un composé supplémentaire est sélectionné dans le groupe. Les deux ensembles sont analysés de nouveau pour identifier le composé dans les ensembles. Une matrice de cooccurrence est calculée. Elle quantifie la cooccurrence du composé et de chacun des deux, ou plus, composés dans les ensembles. Si aucune quantité de cooccurrence pour le composé et chacun des deux, ou plus, composés dans la matrice n'est inférieure à un seuil, les deux, ou plus, composés sont vérifiés.
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