WO2023031788 - T7 RNA POLYMERASE VARIANTS FOR RNA SYNTHESIS
National phase entry:
Publication Number
WO/2023/031788
Publication Date
09.03.2023
International Application No.
PCT/IB2022/058118
International Filing Date
30.08.2022
Title **
[English]
T7 RNA POLYMERASE VARIANTS FOR RNA SYNTHESIS
[French]
VARIANTS D'ARN POLYMÉRASE T7 POUR LA SYNTHÈSE D'ARN
Applicants **
GLAXOSMITHKLINE BIOLOGICALS SA
Rue de l'Institut 89
B-1330 Rixensart, BE
Inventors
DORR, Brent M.
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
JELIAZKOV, Jeliazko
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
MELBY, Joel
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
RUDRAPPA, Deepak
1250 South Collegeville Road
Collegeville, Pennsylvania 19426, US
VAIDYA, Nilesh
14200 Shady Grove Road
Rockville, Maryland 20850, US
Priority Data
63/239,458
01.09.2021
US
63/395,070
04.08.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| Entry into National Phase under |
Chapter I
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| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2139 | |
| EPO | Filing, Examination | 11163 | |
| Japan | Filing | 594 | |
| South Korea | Filing | 608 | |
| USA | Filing, Examination | 9360 |
Total: 23864 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides T7 RNA polymerase variants, the use of which increases transcription efficiency and improves the quality and yield of the enzyme. Also provided are polynucleotides encoding the T7 RNA polymerase variants, host cells capable of expressing the T7 RNA polymerase variants, and methods of using the T7 RNA polymerase variants for high-efficiency transcription.[French]
La présente invention concerne des variants d'ARN polymérase T7, l'utilisation de ceux-ci augmentant l'efficacité de transcription et améliorant la qualité et le rendement de l'enzyme. L'invention concerne également des polynucléotides codant pour les variants d'ARN polymérase T7, des cellules hôtes capables d'exprimer les variants d'ARN polymérase T7, ainsi que des procédés d'utilisation des variants d'ARN polymérase T7 pour une transcription à haut rendement.