WO2023037182 - AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- α -METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
National phase entry:
Publication Number
WO/2023/037182
Publication Date
16.03.2023
International Application No.
PCT/IB2022/057782
International Filing Date
19.08.2022
Title **
[English]
AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- α -METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
[French]
PROCESSUS AMÉLIORÉ DE PRÉPARATION DE CHLORHYDRATE DE N-ÉTHYL-α-MÉTHYL-3-(TRIFLUOROMÉTHYL)PHÉNÉTHYLAMINE
Applicants **
BIOPHORE INDIA PHARMACEUTICALS PVT LTD
Inventors
PULLAGURLA, Manik Reddy
PITTA, Bhaskar Reddy
RANGISETTY, Jagadeesh Babu
Priority Data
202141037571
19.08.2021
IN
Application details
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International Searching Authority |
IP India
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1973 | |
| EPO | Filing, Examination, Granting | 11392 | |
| Japan | Filing, Examination, Granting | 2061 | |
| South Korea | Filing, Examination, Granting | 1801 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,967
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to an improved process for the preparation of N-ethyl- α -methyl-3-(trifluoromethyl) phenethylamine hydrochloride (1), having purity greater than 99.5% by HPLC using highly pure 3-(trifluoromethyl) aniline hydrochloride (5) as a key starting material. The present invention provides process for the purification of N-ethyl-α -methyl-3-(trifluoromethyl) phenethylamine hydrochloride (1), which is substantially free of Impurity A and Impurity B.[French]
La présente invention concerne un processus amélioré de préparation de chlorhydrate de N-éthyl-α-méthyl-3-(trifluorométhyl)phénéthylamine (1), ayant une pureté supérieure à 99,5 % par HPLC faisant appel à du chlorhydrate de 3-(trifluorométhyl)aniline (5) à pureté élevée en tant que matériau de départ clé. La présente invention concerne un processus de purification de chlorhydrate de N-éthyl-α-méthyl-3-(trifluorométhyl)phénéthylamine (1), qui est sensiblement exempt d'impuretés A et d'impuretés B (I)