WO2023017484 - CYTOTOXICITY TARGETING CHIMERAS
National phase entry:
Publication Number
WO/2023/017484
Publication Date
16.02.2023
International Application No.
PCT/IB2022/057562
International Filing Date
12.08.2022
Title **
[English]
CYTOTOXICITY TARGETING CHIMERAS
[French]
CHIMÈRES CIBLANT LA CYTOTOXICITÉ
Applicants **
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
980 Great West Road
Brentford Middlesex TW89GS, GB
Inventors
CHEN, Peiling
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
DARCY, Michael Gerard
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
DODSON, Jason W.
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
KNAPP-REED, Beth A.
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
LEACH, Craig
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
LI, Yuehu
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
MARCUS, Andrew Peter
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
MARINO, JR., Joseph Paul
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
OPLINGER, Jeffrey Alan
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
PHELAN, James P.
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
SENDER, Matthew Robert
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
TURUNEN, Brandon
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
YE, Guosen
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
ZHANG, Cunyu
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
JEONG, Jae U.
1250 South Collegeville Road, UP4110
Collegeville, Pennsylvania 19426, US
Priority Data
63/233,144
13.08.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 7615 | |
| EPO | Filing, Examination | 26326 | |
| Japan | Filing | 591 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 12310 |
Total: 47417 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.[French]
La présente invention concerne des molécules hétérobifonctionnelles, appelées chimères ciblant la cytotoxicité (CyTaCs) ou des molécules de recrutement d'anticorps (ARM) qui sont capables de se lier simultanément à une protéine de surface cellulaire cible ainsi qu'à une protéine d'anticorps exogène. La présente invention concerne également des agents capables de se lier à un récepteur sur une surface d'une cellule pathogène et d'induire la déplétion de la cellule pathogène chez un sujet pour une utilisation dans le traitement du cancer, de maladies inflammatoires, de maladies auto-immunes, d'une infection virale ou d'une infection bactérienne.