WO2023012690 - NOVEL OMEGA 3 CARRIER PREPARATIONS FOR INHALATION DRUG DELIVERY FOR TREATING LUNG INFLAMMATION

National phase entry:
Publication Number WO/2023/012690
Publication Date 09.02.2023
International Application No. PCT/IB2022/057208
International Filing Date 03.08.2022
Title **
[English] NOVEL OMEGA 3 CARRIER PREPARATIONS FOR INHALATION DRUG DELIVERY FOR TREATING LUNG INFLAMMATION
[French] NOUVELLES PRÉPARATIONS DE SUPPORT OMÉGA 3 DESTINÉES À L'ADMINISTRATION DE MÉDICAMENT PAR INHALATION POUR LE TRAITEMENT D'UNE INFLAMMATION PULMONAIRE
Applicants **
LEIUTIS PHARMACEUTICALS LLP
Inventors
KOCHERLAKOTA, Chandrashekhar
BRENNA, James Thomas
KOTHAPALLI, Sesha Durga Kumar
BANDA, Nagaraju
NARALA, Arjun
AKULA, Srinath
Priority Data
202141035170   04.08.2021   IN
202141053853   23.11.2021   IN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2758
EPO Filing, Examination, Granting18295
Japan Filing, Examination, Granting2493
South Korea Filing, Examination, Granting2894
USA Filing, Examination, Granting6540
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Total: 32,980

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] Inflammatory disorders of the lung are induced by COVID-19 disease, asthma, and numerous other disorders. Omega- 3 fatty acids (O3FA), particularly docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) or eicosapentaenoic acid (EPA), have known anti-inflammatory and pro-resolving properties. Reduction of lung pathology and inflammation will be accomplished by a mixture incorporating O3FA that is suitable for nebulization using formulas and nebulization apparatus known in the art. The O3FA may be delivered in the form of ethyl esters (EE) or free fatty acid (FEA) oils or non- phosphate- containing glycerolipids or as phospholipids (PL) or as any other form known in the art. The mixture can also be delivered in any of the other forms of inhaled droplet or solids for inhalation known in the art. The patient will inhale for a therapeutically effective period of time to reduce inflammation and improve breathing.[French] Les troubles inflammatoires du poumon sont induits par la maladie COVID-19, l'asthme et de nombreux autres troubles. Les acides gras oméga-3 (O3FA), en particulier l'acide docosahexaénoïque (DHA), l'acide docosapentaénoïque (DPA) ou l'acide eicosapentaénoïque (EPA), ont des propriétés anti-inflammatoires et pro-résolution connues. La réduction de la pathologie pulmonaire et de l'inflammation est effectuée par un mélange incorporant de l'O3FA qui est approprié pour la nébulisation à l'aide de formules et d'un appareil de nébulisation connus dans l'état de la technique. L'O3FA peut être administré sous la forme d'esters éthyliques (EE) ou d'huiles d'acides gras libres (FEA) ou de glycérolipides ne contenant pas de phosphate ou en tant que phospholipides (PL) ou sous toute autre forme connue dans l'état de la technique. Le mélange peut également être administré sous l'une quelconque des autres formes de gouttelettes inhalées ou de solides pour inhalation connues dans l'état de la technique. Le patient inhale pendant une durée thérapeutiquement efficace afin de réduire l'inflammation et d'améliorer la respiration.