WO2023017345 - AMORPHOUS CALCIUM PHOSPHATE CERAMIC-BASED DRUG DELIVERY SYSTEM AND METHOD FOR ITS FABRICATION
National phase entry:
Publication Number
WO/2023/017345
Publication Date
16.02.2023
International Application No.
PCT/IB2022/056873
International Filing Date
26.07.2022
Title **
[English]
AMORPHOUS CALCIUM PHOSPHATE CERAMIC-BASED DRUG DELIVERY SYSTEM AND METHOD FOR ITS FABRICATION
[French]
SYSTÈME D'ADMINISTRATION DE MÉDICAMENT À BASE DE CÉRAMIQUE DE PHOSPHATE DE CALCIUM AMORPHE ET SON PROCÉDÉ DE FABRICATION
Applicants **
RIGAS TEHNISKA UNIVERSITATE
Kipsalas 6A
LV-1048 Riga, LV
Inventors
RUBENIS, Kristaps
Stadiona iela 9
LV-3002 Jelgava, LV
ZEMJANE, Signe
Vaidavas iela 2k-3-144
LV-1084 Riga, LV
LOCS, Janis
Kurmales iela 94-2
LV-2167 Marupe, LV
LOCA, Dagnija
Kurmales iela 94-2
LV-2167 Marupe, LV
Priority Data
LVP2021000045
10.08.2021
LV
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Drawings | * |
| Pages for Publication | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 961 | |
| EPO | Filing, Examination | 4633 | |
| Japan | Filing | 595 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 3310 |
Total: 10073 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present innovation relates to the field of biomaterials, drug delivery systems, load-bearing materials for bone regeneration and dental restauration. The method for fabrication of amorphous calcium phosphate ceramic-based drug delivery system is proposed. According to the method, mixture of amorphous calcium phosphate and at least one drug is sintered at pressure that exceeds 500 MPa, preferably in the range of 600 to 1500 MPa, at temperature from 15 to 35 °C. The selected pressure range allows to obtain on amorphous calcium phosphate ceramic-based long-term drug delivery system with excellent mechanical properties.[French]
La présente invention se rapporte au domaine des biomatériaux, des systèmes d'administration de médicament, des matériaux porteurs de charge permettant la régénération osseuse et la restauration dentaire. Le procédé de fabrication du système d'administration de médicament à base de céramique de phosphate de calcium amorphe est proposé. Selon le procédé, un mélange de phosphate de calcium amorphe et d'au moins un médicament est fritté à une pression qui dépasse 500 MPa, de préférence dans la plage de 600 à 1 500 MPa, à une température comprise entre 15 et 35 °C. La plage de pression sélectionnée permet d'obtenir un système d'administration de médicament à long terme à base de céramique de phosphate de calcium amorphe présentant d'excellentes propriétés mécaniques.