WO2023105290 - SHORT-PULSE SONODYNAMIC TREATMENT APPARATUS
National phase entry:
Publication Number
WO/2023/105290
Publication Date
15.06.2023
International Application No.
PCT/IB2022/000750
International Filing Date
09.12.2022
Title **
[English]
SHORT-PULSE SONODYNAMIC TREATMENT APPARATUS
[French]
APPAREIL DE TRAITEMENT SONODYNAMIQUE PAR IMPULSIONS BRÈVES
Applicants **
INSIGHTEC, LTD.
P.O. Box 2059
39120 Tirat Carmel, IL
Inventors
SHAPIRA, Yeruham
43 Gordon St.
76287 Rehovot, IL
DE PICIOTTO, Rafi
29 Hayasmin St.
9979700 Carmei Yosef, IL
LEVY, Yoav
Tel Menashe 21
Hinanit, IL
MARCUS, Stuart, L.
Sonalasense, Inc.
2600 10th Street, #435
Berkeley, CA 94710, US
Priority Data
63/288,428
10.12.2021
US
63/288,436
10.12.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1295 | |
| EPO | Filing, Examination | 5269 | |
| Japan | Filing | 594 | |
| South Korea | Filing | 608 | |
| USA | Filing, Examination | 2710 |
Total: 10476 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Sonodynamic therapy systems and methods use short, high-pressure ultrasound pulses that produce small (and therefore clinically safe) increases (up to 1-2 °C) in tissue temperature but nonetheless activate sonodynamic agents, allowing isolated single-cavitation events to produce therapeutically beneficial effects (e.g., cytotoxicity) on diseased tissue. An escalating sonication strategy may be employed whereby the focal pressure is gradually increased until maximum clinically tolerable parameters such as the degree of heating of intervening tissue (e.g., the skull when treating brain cancer) or undesired induced cavitation effects are reached.[French]
Des systèmes et des procédés de thérapie sonodynamique utilisent des impulsions ultrasonores courtes et haute pression qui produisent des petites (et donc cliniquement sûres) augmentations (jusqu'à 1-2 °C) dans la température du tissu mais activent cependant des agents sonodynamiques, ce qui permet à des événements monocavitation isolés de produire des effets thérapeutiquement bénéfiques (par exemple, une cytotoxicité) sur un tissu malade. Une stratégie de sonication progressive peut être utilisée, la pression focale étant progressivement augmentée jusqu'à ce que des paramètres cliniquement tolérables maximaux tels que le degré de chauffage de tissu intervenant (par exemple, le crâne lors du traitement du cancer du cerveau) ou des effets de cavitation induits indésirables sont atteints.