WO2023084308 - PROCESS FOR PREPARING COORDINATION POLYMERS
National phase entry is expected:
Publication Number
WO/2023/084308
Publication Date
19.05.2023
International Application No.
PCT/IB2022/000698
International Filing Date
11.11.2022
Title **
[English]
PROCESS FOR PREPARING COORDINATION POLYMERS
[French]
PROCÉDÉ DE PRÉPARATION DE POLYMÈRES DE COORDINATION
Applicants **
THE CHINESE UNIVERSITY OF HONG KONG
Shatin, New Territories
Hon Kong, CN
Inventors
BEYER, Sebastian
Paulstrasse 4
26129 Oldenburg, DE
LAU, Yee Shun, Eson
Flat A, 37/f, Block 12, 398 Castle Peak Road
Tsuen Wan, Nt
Hong Kong, CN
Priority Data
63/263,998
12.11.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
CNIPA
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1286 | |
| EPO | Filing, Examination | 9153 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 2910 |
Total: 14513 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The subject invention pertains to crystalline coordination polymers, such as Zeolitic Imidazolate Frameworks (ZIFs), having transition metals and large or unipolar imidazole derivatives. Specifically, vitamin b-12 co-factors are used to form a ZIF as porous supports to encapsulate drugs or other agents for biomedical applications. The ZIFs can be produced using exclusively non-toxic GRAS reagents and solvents in optimized proportions to promote crystallization over formation of amorphous polymers. A solvent mixture is identified to provide the appropriate balance of polarity and other factors while preparing crystalline coordination polymers involving imidazole derivatives, such as co-factors in vitamin-b-12. Appropriate formulations can include drugs of other agents for treatment of a human or animal.[French]
La présente invention concerne des polymères de coordination cristallins, tels que des structures d'imidazolate zéolitique (ZIF), comportant des métaux de transition et des dérivés d'imidazole grands ou unipolaires. En particulier, des cofacteurs de vitamine b-12 sont utilisés pour former une ZIF en tant que supports poreux pour encapsuler des médicaments ou d'autres agents pour des applications biomédicales. Les ZIF peuvent être produites à l'aide de réactifs GRAS non toxiques et de solvants en des proportions optimisées pour favoriser la cristallisation pendant la formation de polymères amorphes. Un mélange de solvants est identifié pour fournir l'équilibre approprié de polarité et d'autres facteurs tout en préparant des polymères de coordination cristallins impliquant des dérivés d'imidazole, tels que des cofacteurs dans la vitamine b-12. Des formulations appropriées peuvent comprendre des médicaments d'autres agents pour le traitement d'un être humain ou d'un animal.