WO2023007241 - COMPOSITIONS AND METHODS RELATED TO TET-ASSISTED PYRIDINE BORANE SEQUENCING FOR CELL-FREE DNA
National phase entry:
Publication Number
WO/2023/007241
Publication Date
02.02.2023
International Application No.
PCT/IB2022/000420
International Filing Date
26.07.2022
Title **
[English]
COMPOSITIONS AND METHODS RELATED TO TET-ASSISTED PYRIDINE BORANE SEQUENCING FOR CELL-FREE DNA
[French]
COMPOSITIONS ET PROCÉDÉS LIÉS AU SÉQUENÇAGE DE PYRIDINE BORANE ASSISTÉ PAR TET POUR ADN ACELLULAIRE
Applicants **
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
University Offices, Wellington Square
Oxford, Oxfordshire OX1 2JD, GB
Inventors
SONG, Chunxiao
c/o The Chancellor, Masters And Scholars Of The
University Of Oxford
University Offices, Wellington Square
Oxford
Oxfordshire OX1 2JD, GB
SIEJKA-ZIELIŃSKA, Paulina
c/o The Chancellor, Masters And Scholars Of The
University Of Oxford
University Offices, Wellington Square
Oxford
Oxfordshire OX1 2JD, GB
CHENG, Jingfei
c/o The Chancellor, Masters And Scholars Of The
University Of Oxford
University Offices, Wellington Square
Oxford
Oxfordshire OX1 2JD, GB
JACKSON, Felix
c/o The Chancellor, Masters And Scholars Of The
University Of Oxford
University Offices, Wellington Square
Oxford
Oxfordshire OX1 2JD, GB
LIU, Ybin
c/o The Chancellor, Masters And Scholars Of The
University Of Oxford
University Offices, Wellington Square
Oxford
Oxfordshire OX1 2JD, GB
Priority Data
63/203,565
27.07.2021
US
Application details
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 2349 | |
| EPO | Filing, Examination | 16606 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 8110 |
Total: 28229 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure provides compositions and methods related to TET-assisted Pyridine Borane Sequencing (TAPS). In particular, the present disclosure provides optimized TAPS for cfDNA (cfTAPS), which provides high-quality and high-depth whole-genome cell-free methylomes. The compositions and methods provided herein facilitate the acquisition of multimodal information about cfDNA characteristics, including DNA methylation, tissue of origin, and DNA fragmentation for the diagnosis and treatment of disease.[French]
La présente invention concerne des compositions et des procédés liés au séquençage pyridine-borane assisté par TET (TAPS). Plus particulièrement, la présente invention concerne le TAPS optimisé pour l'ADNcf (cfTAPS), permettant d'obtenir des méthylomes acellulaires du génome entier de haute qualité et de grande profondeur. Les compositions et les procédés présentés ici facilitent l'acquisition d'informations multimodales sur les caractéristiques de l'ADNcf, y compris la méthylation de l'ADN, le tissu d'origine et la fragmentation de l'ADN, pour le diagnostic et le traitement des maladies.