WO2023161668 - COMPOSITIONS AND METHODS FOR TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS

National phase entry:
Publication Number WO/2023/161668
Publication Date 31.08.2023
International Application No. PCT/IB2022/000089
International Filing Date 28.02.2022
Title **
[English] COMPOSITIONS AND METHODS FOR TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS
[French] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA FIBROSE PULMONAIRE IDIOPATHIQUE
Applicants **
NUFORMIX TECHNOLOGIES LIMITED 6th Floor, 60 Gracechurch Street London EC3V 0HR, GB
Inventors
HOLLAND, Joanne 20B Pages Close, Histon Cambridge, Cambridgeshire, CB24 9HF, GB
BORTHWICK, Lee The University of Newcastle Upon Tyne King's Gate, Newcastle upon Tyne NE1 7RU, GB
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Quotation for National Phase entry

Country StagesTotal
China Filing1429
EPO Filing, Examination7874
Japan Filing589
South Korea Filing482
USA Filing, Examination6910
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Total: 17284

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Abstract[English] The treatment of idiopathic pulmonary fibrosis (IPF) using a therapeutically effective amount of a combination of tranilast and pirfenidone, or a therapeutically effective amount of a combination of tranilast and nintedanib, is described. Tranilast may be administered as an adjunctive therapy to the treatment of IPF by either pirfenidone or nintedanib. The combination of tranilast and pirfenidone and the combination of tranilast and nintedanib may also be synergistically effective to treat IPF. Methods and pharmaceutical compositions for treating idiopathic pulmonary fibrosis (IPF) are also described.[French] L'invention concerne le traitement de la fibrose pulmonaire idiopathique (IPF) à l'aide d'une quantité thérapeutiquement efficace d'une combinaison de tranilast et de pirfénidone, ou d'une quantité thérapeutiquement efficace d'une combinaison de tranilast et de nintedanib. Le tranilast peut être administré en tant que thérapie d'appoint au traitement de l'IPF par la pirfénidone ou le nintedanib. La combinaison de tranilast et de pirfénidone et la combinaison de tranilast et de nintedanib peuvent également être efficaces de manière synergique pour traiter l'IPF. L'invention concerne également des méthodes et des compositions pharmaceutiques pour le traitement de la fibrose pulmonaire idiopathique (IPF).
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