WO2024194662 - PROCESS FOR THE PREPARATION OF UPADACITINIB

National phase entry:
Publication Number WO/2024/194662
Publication Date 26.09.2024
International Application No. PCT/HU2024/050019
International Filing Date 22.03.2024
Title **
[English] PROCESS FOR THE PREPARATION OF UPADACITINIB
[French] PROCÉDÉ DE PRÉPARATION D'UPADACITINIB
Applicants **
EGIS GYÓGYSZERGYÁR ZRT.
Inventors
MÁNDI, Géza
NAGY, Tamás
PORCS-MAKKAY, Márta
ABONYI, Attila László
KURUNCZI, Erika
Priority Data
P2300098   23.03.2023   HU
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2180
EPO Filing, Examination, Granting11950
Japan Filing, Examination, Granting2243
South Korea Filing, Examination, Granting2019
USA Filing, Examination, Granting5530
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Total: 23,922

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Abstract[English] The object of the invention is the preparation of upadacitinib drug substance of the formula (I) by a new process, which is novel, environmentally friendly, has an advantageous pollution profile, and also can be realized on an industrial scale, using novel intermediates not yet known from the literature.[French] L'objet de l'invention est la préparation d'une substance médicamenteuse, l'upadacitinib, de formule (I) au moyen d'un nouveau procédé, qui est nouveau, respectueux de l'environnement, a un profil de pollution avantageux, et peut également être mis en oeuvre à l'échelle industrielle, à l'aide de nouveaux intermédiaires non encore connus de la littérature.

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