WO2025215348 - SKIN WOUND TREATMENT
National phase entry is expected:
Publication Number
WO/2025/215348
Publication Date
16.10.2025
International Application No.
PCT/GB2025/050736
International Filing Date
07.04.2025
Title **
[English]
SKIN WOUND TREATMENT
[French]
TRAITEMENT DE PLAIE CUTANÉE
Applicants **
THE BOOTS COMPANY PLC
Inventors
BELL, Michael
BRADLEY, Eleanor
ECKERSLEY, Alexander
OZOLS, Matiss
EL HOUNI, Zeyad
SHERRATT, Michael
HERRICK, Sarah
Priority Data
24020112.9
08.04.2024
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1880 | |
| EPO | Filing, Examination, Granting | 8126 | |
| Japan | Filing, Examination, Granting | 1877 | |
| South Korea | Filing, Examination, Granting | 1505 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
18,128
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Abstract[English]
According to the present invention, there is provided a pharmaceutical composition for use in a method of treating a wound in the skin of a subject and methods of using the pharmaceutical composition, the pharmaceutical composition comprising a tetrapeptide having the amino acid sequence U-QTAV-Z wherein Q is used to denote amino acid Glutamine, T is used to denote amino acid Threonine, A is used to denote amino acid Alanine and V is used to denote amino acid Valine. At the N-terminal end, U is independently selected from the group consisting of octanoyl (C8), decanoyl (C10), lauroyl (C12), myristoyl (C14), palmitoyl (C16), stearoyl (C18), biotinoyl, elaidoyl, oleoyle, lipoyle. At the C-terminal end, Z is selected from the group consisting of OH, O R1, NHR1 or NR1R2. R1 and R2 are independently selected from the group consisting of alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclical, polycyclic, unsaturated, hydroxylates, carbonylated, phosphorylated and/or sulphurous, said groups comprising from 1 to 24 carbon atoms and being capable of including one or more heteroatoms O, S and/or N.[French]
La présente invention concerne une composition pharmaceutique destinée à être utilisée dans une méthode de traitement d'une plaie sur la peau d'un sujet et des méthodes d'utilisation de la composition pharmaceutique, la composition pharmaceutique comprenant un tétrapeptide ayant la séquence d'acides aminés U-QTAV-Z, Q étant utilisé pour désigner l'acide aminé Glutamine, T étant utilisé pour désigner l'acide aminé thréonine, A étant utilisé pour désigner l'acide aminé alanine et V étant utilisé pour désigner l'acide aminé valine. Au niveau de l'extrémité N-terminale, U est indépendamment choisi dans le groupe constitué par octanoyle (C8), décanoyle (C10), lauroyle (C12), myristoyle (C14), palmitoyle (C16), stéaroyle (C18), biotinoyle, élaïdoyle, oléoyle, lipoyle. Au niveau de l'extrémité C-terminale, Z est choisi dans le groupe constitué par OH, O R1, NHR1 ou NR1R2. R1 et R2 sont indépendamment choisis dans le groupe constitué par les groupes alkyle, aryle, aralkyle, alkylaryle, alcoxy, saccharide et aryloxy, qui peuvent être linéaires, ramifiés, cycliques, polycycliques, insaturés, hydroxylates, carbonylés, phosphorylés et/ou soufrés, lesdits groupes comprenant de 1 à 24 atomes de carbone et pouvant comprendre un ou plusieurs hétéroatomes O, S et/ou N.