WO2026115037 - TRI-AGONISTS OF THE GLP-1, GIP, AND AMYLIN RECEPTORS AND USES THEREOF

National phase entry is expected:
Publication Number WO/2026/115037
Publication Date 04.06.2026
International Application No. PCT/EP2025/084534
International Filing Date 27.11.2025
Title **
[English] TRI-AGONISTS OF THE GLP-1, GIP, AND AMYLIN RECEPTORS AND USES THEREOF
[French] TRI-AGONISTES DES RÉCEPTEURS GLP-1, GIP ET AMYLINE ET LEURS UTILISATIONS
Applicants **
NOVO NORDISK A/S
Inventors
KRUSE, Thomas
LAU, Jesper, F.
MADSEN, Charlotte, Stahl
HAXVIG, Christina, Sophie
Priority Data
PCT/EP2024/084031   29.11.2024   EP
25179080.4   27.05.2025   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting9484
EPO Filing, Examination, Granting279848
Japan Filing, Examination, Granting5601
South Korea Filing, Examination, Granting15840
USA Filing, Examination, Granting52890
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Total: 363,663
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Abstract[English] The present invention provides a GLP-1-/GIP-/amylin-receptor tri-agonist having a balanced potency ratio across all three receptors and/or having improved pharmacokinetic properties. The invention also provides pharmaceutical compositions comprising such a GLP-1-/GIP-/amylin-receptor tri-agonist as well as their use as a medicament for the treatment of subjects with overweight, obesity and associated co-morbidity.[French] La présente invention concerne un tri-agoniste des récepteurs GLP-1, GIP et amyline présentant un rapport de puissance équilibré sur les trois récepteurs et/ou présentant des propriétés pharmacocinétiques améliorées. L'invention concerne également des compositions pharmaceutiques comprenant un tel tri-agoniste des récepteurs GLP-1, GIP et amyline, ainsi que leur utilisation en tant que médicament pour le traitement de sujets présentant un surpoids, une obésité et des comorbidités associées.