WO2026047215 - PROTEIN NANOFIBRILS AS COFORMULANT
National phase entry is expected:
Publication Number
WO/2026/047215
Publication Date
05.03.2026
International Application No.
PCT/EP2025/074703
International Filing Date
29.08.2025
Title **
[English]
PROTEIN NANOFIBRILS AS COFORMULANT
[French]
NANOFIBRILLES PROTÉIQUES EN TANT QUE CO-FORMULANT
Applicants **
VIB VZW
VRIJE UNIVERSITEIT BRUSSEL
Inventors
REMAUT, Han
SLEUTEL, Mike
SOGUES CASTREJON, Adria
Priority Data
PCT/EP2024/074370
30.08.2024
EP
25162107.4
06.03.2025
EP
Application details
| Total Number of Claims/PCT | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2466 | |
| EPO | Filing, Examination, Granting | 10045 | |
| Japan | Filing, Examination, Granting | 2186 | |
| South Korea | Filing, Examination, Granting | 2168 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
22,805
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Abstract[English]
The present invention relates to the field of protein nanofibrils originating from Bacillus sp. provided in a composition as additive to a biologically active substance, in particular to a microbial substance such as a pesticide or plant beneficial agent. More specifically, the present invention relates to a composition comprising an agriculturally bioactive substance and Alpha(helical) Endospore appendage (A-ENA) protein nanofibril materials, more precisely wherein said A-ENA protein nanofibrils are recombinantly produced and exogenously added to said bioactive substance of the composition, thereby functioning as coformulant or additive, and preferably increasing the biological activity of said substance. In particular, the composition of the invention comprises B. thuringiensis spores or cells and self-assembled (engineered or functionalized) A-ENA protein nanofibrils as coformulant, providing for an improved efficacy and/or application potential as pesticide or insecticide. The present invention further relates to a method for controlling plant growth and protection of plants or parts thereof from pest damage, in particular by applying said composition of the invention in an effective amount or formulation, wherein the presence of said A-ENA protein nanofibril coformulant or additive results in increased efficacy and/or virulence of the bioactive substance of said composition, in particular for bioactive substances comprising Bacillus sp. strains.[French]
La présente invention appartient au domaine des nanofibrilles protéiques provenant de Bacillus sp. fournies dans une composition en tant qu'additif à une substance biologiquement active, en particulier à une substance microbienne telle qu'un pesticide ou un agent bénéfique pour les plantes. Plus particulièrement, la présente invention concerne une composition contenant une substance bioactive sur le plan agricole et des matériaux de type nanofibrilles protéiques d'appendice d’endospore (A-ENA) alpha (hélicoïdales), plus précisément lesdites nanofibrilles protéiques A-ENA étant produites par recombinaison et ajoutées de manière exogène à ladite substance bioactive de la composition, fonctionnant ainsi en tant que co-formulant ou additif, et augmentant de préférence l'activité biologique de ladite substance. En particulier, la composition de l'invention contient des spores ou des cellules de B. thuringiensis et des nanofibrilles protéiques A-ENA auto-assemblées (modifiées ou fonctionnalisées) en tant que co-formulant, assurant une efficacité et/ou un potentiel d'application améliorés en tant que pesticide ou insecticide. La présente invention concerne en outre un procédé de régulation de la croissance de plantes et de protection de plantes ou de parties de celles-ci contre des dommages causés par les nuisibles, en particulier par application de ladite composition de l'invention dans une quantité ou une formulation efficace, la présence dudit co-formulant ou additif à base de nanofibrilles protéiques A-ENA entraînant une efficacité et/ou une virulence accrues de la substance bioactive de ladite composition, en particulier pour des substances bioactives contenant des souches de Bacillus sp.