WO2026008664 - ALLOSTERIC MODULATORS OF INHIBITORY IMMUNE RECEPTOR COMPLEXES
National phase entry is expected:
Publication Number
WO/2026/008664
Publication Date
08.01.2026
International Application No.
PCT/EP2025/068743
International Filing Date
01.07.2025
Title **
[English]
ALLOSTERIC MODULATORS OF INHIBITORY IMMUNE RECEPTOR COMPLEXES
[French]
MODULATEURS ALLOSTÉRIQUES DE COMPLEXES DE RÉCEPTEURS IMMUNITAIRES INHIBITEURS
Applicants **
VIB VZW
VRIJE UNIVERSITEIT BRUSSEL
Inventors
STEYAERT, Jan
WOHLKÖNIG, Alexandre
ZÖGG, Thomas
MIGLIANICO, Marie
Priority Data
24185761.4
01.07.2024
EP
25185826.2
27.06.2025
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4282 | |
| EPO | Filing, Examination, Granting | 22014 | |
| Japan | Filing, Examination, Granting | 2553 | |
| South Korea | Filing, Examination, Granting | 2921 | |
| USA | Filing, Examination, Granting | 9940 |
Total:
41,710
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Abstract[English]
This disclosure relates to an immunoglobulin single variable domain (ISVD)-containing modulator that allosterically binds to a three-dimensional (3D) epitope of a protein complex comprising at least one inhibitory immune receptor and at least one corresponding ligand. The modulator regulates cooperativity within such complexes, thereby affecting the binding affinity and downstream signaling pathways. Specifically, the allosteric modulator of this invention induces positive cooperativity in immunoinhibitory receptor-ligand complexes, thus suppressing immune responses in a spatiotemporally restricted manner. Accordingly, these allosteric modulators are useful as therapeutic agents for inflammatory diseases, such as autoimmune diseases, allergic diseases, or graft-versus-host disease (GVHD). Moreover, this disclosure pertains to methods for identifying, selecting, and producing said allosteric modulators.[French]
La présente divulgation concerne un modulateur contenant un domaine variable unique d'immunoglobuline (ISVD) qui se lie de manière allostérique à un épitope tridimensionnel (3D) d'un complexe protéique comprenant au moins un récepteur immunitaire inhibiteur et au moins un ligand correspondant. Le modulateur régule la coopérativité dans ces complexes, affectant ainsi les voies d'affinité de liaison et de signalisation en aval. Plus particulièrement, le modulateur allostérique selon la présente invention induit une coopérativité positive dans des complexes récepteur-ligand immunoinhibiteurs, supprimant ainsi des réponses immunitaires de manière spatio-temporelle restreinte. En conséquence, ces modulateurs allostériques sont utiles en tant qu'agents thérapeutiques pour des maladies inflammatoires telles que des maladies auto-immunes, des maladies allergiques ou une maladie du greffon contre l'hôte (GVHD). De plus, la présente divulgation concerne des procédés d'identification, de sélection et de production desdits modulateurs allostériques.