WO2024261237 - FLUOROMETHYL-CARNITINE FOR USE AS A CHOLINE TRIMETHYLAMINE (TMA) LYASE INHIBITOR
National phase entry is expected:
Publication Number
WO/2024/261237
Publication Date
26.12.2024
International Application No.
PCT/EP2024/067429
International Filing Date
21.06.2024
Title **
[English]
FLUOROMETHYL-CARNITINE FOR USE AS A CHOLINE TRIMETHYLAMINE (TMA) LYASE INHIBITOR
[French]
FLUOROMÉTHYL-CARNITINE DESTINÉE À ÊTRE UTILISÉE COMME INHIBITEUR DE LA CHOLINE TRIMÉTHYLAMINE (TMA) LYASE
Applicants **
ALFASIGMA S.P.A.
Via Ragazzi del '99 n.5
40133 Bologna (BO), IT
Inventors
GIANNINI, Giuseppe
c/o ALFASIGMA SpA
Via Pontina, Km 30, 400
00071 Pomezia (RM), IT
BATTISTUZZI, Gianfranco
c/o ALFASIGMA SpA
Via Pontina, Km 30, 400
00071 Pomezia (RM), IT
TADDEI, Maurizio
c/o DIPARTIMENTO DI BIOTECNOLOGIE, CHIMICA E FARMACIA
Università degli Studi di Siena
via Aldo Moro, 2
53100 Siena, IT
CINI, Elena
c/o DIPARTIMENTO DI BIOTECNOLOGIE, CHIMICA E FARMACIA
Università degli Studi di Siena
via Aldo Moro, 2
53100 Siena, IT
Priority Data
102023000012522
22.06.2023
IT
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1454 | |
| EPO | Filing, Examination | 6744 | |
| Japan | Filing | 588 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 2710 |
Total: 12070 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to a compound of formula (I) for use in the treatment of disorders and/or conditions associated with high trimethylamine (TMA) and/or trimethylamine N-oxide (TMAO) plasma levels, or for use in the treatment of disorders and/or conditions associated with a high ratio of TMA/TMAO plasma concentrations as well as relative composition and method of preparation.[French]
La présente invention concerne un composé de formule (I) destiné à être utilisé dans le traitement de troubles et/ou d'états pathologiques associés à des taux plasmatiques élevés de triméthylamine (TMA) et/ou de N-oxyde de triméthylamine (TMAO), ou destiné à être utilisé dans le traitement de troubles et/ou d'états pathologiques associés à un rapport élevé de concentrations plasmatiques de TMA/TMAO, ainsi qu'une composition et un procédé de préparation correspondants.