WO2024246216 - METHOD AND SYSTEM FOR PROBABILISTIC TYPING OF MICROBIAL STRAINS
National phase entry is expected:
Publication Number
WO/2024/246216
Publication Date
05.12.2024
International Application No.
PCT/EP2024/064927
International Filing Date
30.05.2024
Title **
[English]
METHOD AND SYSTEM FOR PROBABILISTIC TYPING OF MICROBIAL STRAINS
[French]
PROCEDE ET SYSTEME DE TYPAGE PROBABILISTE DE SOUCHES MICROBIENNES
Applicants **
BIOMÉRIEUX
69280 MARCY L'ETOILE, FR
Inventors
POUSEELE, Hannes
Lepelaarstraat 1
8400 Oostende, BE
TETREAU, Guillaume
2 impasse des Léchères
38240 Meylan, FR
CARRIÇO, Joao Andre
Praça Teófilo Braga 7 7 esq
2650-074 Amadora, PT
Priority Data
23176321.0
31.05.2023
EP
Application details
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1268 | |
| EPO | Filing, Examination | 5745 | |
| Japan | Filing | 533 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 3835 |
Total: 11956 USD
Abstract[English]
The invention relates to a microbiological typing method, which comprises providing a database of genetic profiles of microbial strains, a phylogenetic tree, assignments of the genetic profiles to positions in the phylogenetic tree, and frequencies of variation of the profiles in the tree. The typing of a microorganism comprises measuring the genetic profile of the microorganism, determining probabilities of variation of the genetic profiles belonging to the groups with respect to the measured genetic profile, the probabilities of variation being calculated as a function of the frequencies of variation at a predefined level of the phylogenetic tree and of the belonging of the microorganism to one of the microbial groups if an identification performance criterion is reached for the group, the criterion being reached if at least one probability of variation for the group is greater than a first predefined threshold.[French]
Un procédé de typage microbiologique comprend la fourniture d'une base de données de profils génétiques de souches microbiennes, un arbre phylogénétique, des assignations des profils génétiques à des positions dans l'arbre phylogénétique, et des fréquences de variation des profils dans l'arbre. Le typage d'un microorganisme comprend la mesure du profil génétique du microorganisme, la détermination de probabilités de variation des profils génétiques appartenant auxdits groupes par rapport au profil génétique mesuré, lesdites probabilités de variation étant calculées en fonction des fréquences de variation à un niveau prédéfini de l'arbre phylogénétique et de l'appartenance du microorganisme à l'un des groupes microbien si un critère de performance d'identification est atteint pour ledit groupe, ledit critère étant atteint si au moins une probabilité de variation pour ledit groupe est supérieure à un premier seuil prédéfini.