WO2024231348 - SLC4A4/NBCE1 INHIBITORS

National phase entry:
Publication Number WO/2024/231348
Publication Date 14.11.2024
International Application No. PCT/EP2024/062462
International Filing Date 06.05.2024
Title **
[English] SLC4A4/NBCE1 INHIBITORS
[French] INHIBITEURS DE SLC4A4/NBCE1
Applicants **
VIB VZW
KATHOLIEKE UNIVERSITEIT LEUVEN
VRIJE UNIVERSITEIT BRUSSEL
Inventors
MAZZONE, Massimiliano
ORBAN, Marie-Pauline
BRUNNER, Janine
SCHENK, Stephan
DOMBRECHT, Bruno
LANGENBERG, Tobias
CURCIO, Michele
HASSANZADEH GHASSABEH, Gholamreza
Priority Data
23172907.0   11.05.2023   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2757
EPO Filing, Examination, Granting12458
Japan Filing, Examination, Granting2277
South Korea Filing, Examination, Granting2340
USA Filing, Examination, Granting7590
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Total: 27,422

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Abstract[English] The disclosure relates to the compounds selectively inhibiting Solute Carrier Family 4 member 4/ Electrogenic Sodium Bicarbonate Cotransporter 1 (SLC4A4/NBCe1). More in particular, said compounds are SLC4A4/NBCe1-inhibiting single domain antibodies, compounds comprising at least one CDR polypeptide of a SLC4A4/NBCe1-inhibiting single domain antibody, and compounds comprising a SLC4A4/NBCe1-inhibiting single domain antibody. Applications of compounds inhibiting SLC4A4/NBCe1 are likewise included.[French] La divulgation concerne des composés inhibant sélectivement l'élément 4 de la famille 4 des porteurs de soluté/le cotransporteur 1 de bicarbonate de sodium électrogène (SLC4A4/NBCe1). Plus particulièrement, lesdits composés sont des anticorps à domaine unique inhibant SLC4A4/NBCe1, des composés comprenant au moins un polypeptide CDR d'un anticorps à domaine unique inhibant SLC4A4/NBCe1, et des composés comprenant un anticorps à domaine unique inhibant SLC4A4/NBCe1. Des utilisations des composés inhibant SLC4A4/NBCe1 sont également divulguées.