WO2024156921 - PROTEASOMAL DEGRADATION OF PROTEINS
National phase entry is expected:
Publication Number
WO/2024/156921
Publication Date
02.08.2024
International Application No.
PCT/EP2024/052079
International Filing Date
29.01.2024
Title **
[English]
PROTEASOMAL DEGRADATION OF PROTEINS
[French]
DÉGRADATION PROTÉASOMIQUE DE PROTÉINES
Applicants **
KATHOLIEKE UNIVERSITEIT LEUVEN
KU Leuven R & D Waaistraat 6 - box 5105
3000 Leuven, BE
Inventors
DAELEMANS, Dirk
Sint-Jobsstraat 17
3400 Ezemaal, BE
KWANTEN, Bert
Aarschotsebaan 4A
3370 Boutersem, BE
Priority Data
23153630.1
27.01.2023
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1017 | |
| EPO | Filing, Examination | 4798 | |
| Japan | Filing | 594 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 2635 |
Total: 9619 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The invention relates to methods of identifying a small molecule that promotes ASB (Ankyrin repeat and SOCS box protein) mediated degradation of a target protein, comprising the step of: - providing in vitro conditions allowing the binding of a small molecule and the protein target, and - determining whether binding of the small molecule to the target protein results in the binding of an ASB protein to the target protein, wherein a small molecule that results in the binding of an ASB protein to a target protein with the small molecule, is a candidate medicinal compound for conditions wherein a target protein is to be degraded.[French]
L'invention concerne des méthodes d'identification d'une petite molécule qui favorise la dégradation médiée par ASB (répétition ankyrine et protéine de la boîte SOCS) d'une protéine cible, comprenant l'étape consistant à : - fournir des conditions in vitro permettant la liaison d'une petite molécule et de la cible protéique, et - déterminer si la liaison de la petite molécule à la protéine cible entraîne la liaison d'une protéine ASB à la protéine cible, une petite molécule qui conduit à la liaison d'une protéine ASB à une protéine cible avec la petite molécule, étant un composé médicinal candidat pour des conditions dans lesquelles une protéine cible doit être dégradée.