WO2023213779 - NOVEL ANTI-ANGPTL3 ANTIBODIES SUITABLE FOR HIGH CONCENTRATION COMPOSITIONS AND SUBCUTANEOUS ADMINISTRATION

National phase entry:
Publication Number WO/2023/213779
Publication Date 09.11.2023
International Application No. PCT/EP2023/061478
International Filing Date 02.05.2023
Title **
[English] NOVEL ANTI-ANGPTL3 ANTIBODIES SUITABLE FOR HIGH CONCENTRATION COMPOSITIONS AND SUBCUTANEOUS ADMINISTRATION
[French] NOUVEAUX ANTICORPS ANTI-ANGPTL3 APPROPRIÉS POUR DES COMPOSITIONS À CONCENTRATION ÉLEVÉE ET ADMINISTRATION SOUS-CUTANÉE
Applicants **
NOVO NORDISK A/S
Inventors
HENRIKSEN, Anette
KROGH, Thomas Nylandsted
GREISEN, Per j.
EGEBJERG, Thomas
Priority Data
22171090.8   02.05.2022   EP
22201248.6   13.10.2022   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2601
EPO Filing, Examination, Granting11670
Japan Filing, Examination, Granting2310
South Korea Filing, Examination, Granting2328
USA Filing, Examination, Granting5940
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Total: 24,849

The term for entry into the National Phase has expired. This quotation is for informational purposes only

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Abstract[English] The present invention relates to novel monovalent anti-ANGPTL3 antibodies for use in medicine and in particular for lowering of plasma triglycerides levels in patients in need thereof, such as patients suffering from or at risk of hypertriglyceridemia and/or cardiovascular disease, such as atherosclerotic cardiovascular disease (ASCVD) as well as pharmaceutical compositions suitable for subcutaneous administration and kits comprising such compounds and compositions.[French] La présente invention concerne de nouveaux anticorps anti-ANGPTL3 monovalents destinés à être utilisés en médecine et en particulier pour abaisser les taux de triglycérides plasmatiques chez des patients qui en ont besoin, tels que des patients atteints ou à risque d'hypertriglycéridémie et/ou de maladie cardiovasculaire, tels que la maladie cardiovasculaire athérosclérotique (ASCVD) ainsi que des compositions pharmaceutiques appropriées pour une administration sous-cutanée et des kits comprenant de tels composés et compositions.