WO2023166168 - POLYSTYRENE SULFONATE FOR USE TO TREAT NEURODEGENERATIVE DISEASES
National phase entry is expected:
Publication Number
WO/2023/166168
Publication Date
07.09.2023
International Application No.
PCT/EP2023/055419
International Filing Date
03.03.2023
Title **
[English]
POLYSTYRENE SULFONATE FOR USE TO TREAT NEURODEGENERATIVE DISEASES
[French]
SULFONATE DE POLYSTYRÈNE DESTINÉ À ÊTRE UTILISÉ POUR TRAITER DES MALADIES NEURODÉGÉNÉRATIVES
Applicants **
VIB VZW
Suzanne Tassierstraat 1
9052 Gent, BE
VRIJE UNIVERSITEIT BRUSSEL
Pleinlaan 2
1050 Brussel, BE
KATHOLIEKE UNIVERSITEIT LEUVEN
KU LEUVEN R&D
Waaistraat 6 - bus 5105
3000 Leuven, BE
Inventors
TOMPA, Peter
Mollenberg 17
3090 Overijse, BE
BRATEK-SKICKI, Anna
Avenue de la Palette 13/101
1348 Louvain-La-Neuve, BE
AHMED, Junaid
Waterloosesteenweg 289
1060 Brussel, BE
Priority Data
22159883.2
03.03.2022
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1475 | |
| EPO | Filing, Examination | 7212 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 4110 |
Total: 13961 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to the field of neurological diseases, particularly to neurodegenerative diseases caused by dipeptide repeat toxicity. The invention provides polystyrene sulfonate or a derivative thereof for use as a medicine to inhibit dipeptide repeat toxicity in a subject, to reduce axonal defects in a subject's neurons, and to treat neurological disorders related to the presence of dipeptide repeat toxicity, such as amyotrophic lateral sclerosis and frontotemporal dementia.[French]
La présente invention concerne le domaine des maladies neurologiques, en particulier des maladies neurodégénératives provoquées par une toxicité de répétition dipeptidique. L'invention concerne un sulfonate de polystyrène ou un dérivé de celui-ci destiné à être utilisé en tant que médicament pour inhiber la toxicité de répétitions dipeptidiques chez un sujet, pour réduire les défauts axonaux dans les neurones d'un sujet, et pour traiter des troubles neurologiques associés à la présence d'une toxicité de répétition dipeptidique, telle que la sclérose latérale amyotrophique et la démence frontotemporale.