WO2023152145 - SENSOR MEASUREMENT COMPENSATION IN BIOPROCESSING SYSTEMS
National phase entry:
Publication Number
WO/2023/152145
Publication Date
17.08.2023
International Application No.
PCT/EP2023/053032
International Filing Date
08.02.2023
Title **
[English]
SENSOR MEASUREMENT COMPENSATION IN BIOPROCESSING SYSTEMS
[French]
COMPENSATION DE MESURE DE CAPTEUR DANS DES SYSTÈMES DE BIOTRAITEMENT
Applicants **
MERCK PATENT GMBH
Frankfurter Strasse 250
64293 Darmstadt, DE
Inventors
JOURDAINNE, Laurent
c/o Millipore S.A.S.
39, Route Industrielle de la Hardt
67120 MOLSHEIM, FR
COTON, Thomas
c/o Millipore S.A.S.
39, Route Industrielle de la Hardt
67120 MOLSHEIM, FR
DA SILVA, Anthony
c/o Millipore S.A.S.
39, Route Industrielle de la Hardt
67120 MOLSHEIM, FR
SPINDLER, Quentin
c/o Millipore S.A.S.
39, Route Industrielle de la Hardt
67120 MOLSHEIM, FR
Priority Data
22305153.3
11.02.2022
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 146 | |
| EPO | Filing, Examination | 4063 | |
| Japan | Filing | 501 | |
| South Korea | Filing | 542 | |
| USA | Filing, Examination | 1460 |
Total: 6712 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
A pH system that is able to compensate for variations in pressure and conductivity is disclosed. The system includes a pH sensor, a pressure sensor and optionally a conductivity sensor, the outputs of each are transmitted to a controller. The controller multiplies a compensation coefficient by the difference in pressure between the measured pressure and a threshold pressure. This result is then added to the measured pH value. Further, the compensation coefficient is a function of the conductivity of the solution. In some instances, the compensation coefficient is calculated by raising the conductivity to a power and multiplying that result by a constant. This pH system may be incorporated into various bioprocessing systems, such as multi- column chromatography systems and viral inactivation systems.[French]
Est divulgué un système de pH apte à compenser des variations de pression et de conductivité. Le système comprend un capteur de pH, un capteur de pression et éventuellement un capteur de conductivité, les sorties de chaque capteur étant transmises à un dispositif de commande. Le dispositif de commande multiplie un coefficient de compensation par la différence de pression entre la pression mesurée et une pression seuil. Ce résultat est ensuite ajouté à la valeur de pH mesurée. En outre, le coefficient de compensation est fonction de la conductivité de la solution. Dans certains cas, le coefficient de compensation est calculé en élevant la conductivité à une puissance et en multipliant ce résultat par une constante. Ledit système de pH peut être incorporé dans divers systèmes de biotraitement, tels que des systèmes de chromatographie à colonnes multiples et des systèmes d'inactivation virale.