WO2023135210 - EXTRACELLULAR VESICLES
National phase entry:
Publication Number
WO/2023/135210
Publication Date
20.07.2023
International Application No.
PCT/EP2023/050644
International Filing Date
12.01.2023
Title **
[English]
EXTRACELLULAR VESICLES
[French]
VÉSICULES EXTRACELLULAIRES
Applicants **
KATHOLIEKE UNIVERSITEIT LEUVEN
KU Leuven R & D Waaistraat 6 - box 5105
3000 Leuven, BE
Inventors
DAVID, Guido
Rue D'Elsenbosch 10
1357 Helecine, BE
HYKA, Lukas
V Lukach 1902
25088 Celakovice, CZ
ZIMMERMANN, Pascale
Rue D'Elsenbosch 10
1357 Helecine, BE
Priority Data
22151092.8
12.01.2022
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1592 | |
| EPO | Filing, Examination | 9163 | |
| Japan | Filing | 590 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 4910 |
Total: 16830 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The invention relates to vesicles comprising : 1) a first fusion protein, the first fusion protein comprising: la) a polypeptide capable of binding to a protein on the membrane of a eukaryotic cell, and 2a) a polypeptide capable of binding to syntenin, characterised in that the vesicle further comprises: 2) a second fusion protein, the second fusion protein comprising: 2a) syntenin or a syndecan binding fragment thereof, and 2b) a therapeutic polypeptide, wherein the first fusion protein and the second fusion protein are non-covalenty bound to each other.[French]
L'invention concerne des vésicules comprenant : 1) une première protéine de fusion, la première protéine de fusion comprenant : la) un polypeptide capable de se lier à une protéine sur la membrane d'une cellule eucaryote, et 2a) un polypeptide capable de se lier à la synténine, caractérisées en ce que la vésicule comprend en outre : 2) une seconde protéine de fusion, la seconde protéine de fusion comprenant : 2a) la synténine ou un fragment de liaison de syndécane de celle-ci, et 2b) un polypeptide thérapeutique, la première protéine de fusion et la seconde protéine de fusion étant liées de manière non covalente l'une à l'autre.