WO2023118101 - STACKED BMP INHIBITION FOR NEURAL INDUCTION OF PLURIPOTENT STEM CELLS
National phase entry is expected:
Publication Number
WO/2023/118101
Publication Date
29.06.2023
International Application No.
PCT/EP2022/086932
International Filing Date
20.12.2022
Title **
[English]
STACKED BMP INHIBITION FOR NEURAL INDUCTION OF PLURIPOTENT STEM CELLS
[French]
INHIBITION SUPERPOSÉE DE BMP POUR L'INDUCTION NEURONALE DES CELLULES SOUCHES PLURIPOTENTES
Applicants **
NOVO NORDISK A/S
Novo Allé
2880 Bagsværd, DK
Inventors
NICLIS, Jonathan
Novo Alle 1
2880 Bagsværd, DK
CHRISTIANSEN, Josefine, Rågård
Novo Alle 1
2880 Bagsværd, DK
Priority Data
21216203.6
21.12.2021
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1189 | |
| EPO | Filing, Examination | 4771 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 2710 |
Total: 9834 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
method for differentiating a population of human pluripotent stem cells (hPSCs) into a population of neural cells, wherein neuronal differentiation in said hPSCs is induced by the inhibition of the Small Mothers Against Decapentaplegic (SMAD) signaling pathway by culturing the population of hPSCs in a culture medium comprising two or more inducing factors consisting of two or more inhibitors of the SMAD signaling pathway, wherein a. at least one inhibitor of the SMAD signaling pathway is an inhibitor of a BMP ligand and b. at least one inhibitor of the SMAD signaling pathway is an inhibitor of a BMP receptor, and c. none of the inhibitors of the SMAD signaling pathway is a direct inhibitor of the TGFβ pathway.[French]
de différenciation d'une population de cellules souches pluripotentes humaines (hPSC) en une population de cellules neuronales, la différenciation neuronale dans lesdites hPSC étant induite par l'inhibition de la voie de signalisation Small Mothers Against Decapentaplegic (SMAD) en cultivant la population de hPSC dans un milieu de culture comprenant au moins deux facteurs inducteurs constitués d'au moins deux inhibiteurs de la voie de signalisation SMAD, dans lequel : a) au moins un inhibiteur de la voie de signalisation SMAD est un inhibiteur d'un ligand BMP, b) au moins un inhibiteur de la voie de signalisation SMAD est un inhibiteur d'un récepteur BMP, et c) aucun des inhibiteurs de la voie de signalisation SMAD n'est un inhibiteur direct de la voie TGFβ.