WO2023105074 - PHOTOCHEMICAL APPROACH TO C-TERMINAL A-AMIDATION

National phase entry:
Publication Number WO/2023/105074
Publication Date 15.06.2023
International Application No. PCT/EP2022/085255
International Filing Date 09.12.2022
Title **
[English] PHOTOCHEMICAL APPROACH TO C-TERMINAL A-AMIDATION
[French] APPROCHE PHOTOCHIMIQUE POUR UNE ALPHA-AMIDATION C-TERMINALE
Applicants **
NOVO NORDISK A/S Novo Allé 2880 Bagsværd, DK
Inventors
HARRIS, Michael, Richard Novo Nordisk Research Centre Seattle Inc. 530 Fairview Ave N Seattle, Washington 98109, US
WONG, Sydnee Novo Nordisk Research Centre Seattle Inc. 530 Fairview Ave N Seattle, Washington 98109, US
HYMEL, David, Thomas Novo Nordisk Research Centre Seattle Inc. 530 Fairview Ave N Seattle, Washington 98109, US
HOGENDORF, Wouter, Frederik, Johan Novo Alle 1 2880 Bagsværd, DK
WOJCIK, Felix Novo Alle 1 2880 Bagsværd, DK
COX, Nicholas, Raymond Novo Nordisk Research Centre Seattle Inc. 530 Fairview Ave N Seattle, Washington 98109, US
WILLIAMS, Benjamin, Matthew Novo Alle 1 2880 Bagsværd, DK
MORTENSEN, Asmus, Ringlebjerg Novo Alle 1 2880 Bagsværd, DK
Priority Data
63/288,071   10.12.2021   US
22152378.0   20.01.2022   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing1276
EPO Filing, Examination5259
Japan Filing587
South Korea Filing606
USA Filing, Examination2710
MasterCard Visa

Total: 10438

The term for entry into the National Phase has expired. This quotation is for informational purposes only

Abstract[English] The present invention relates to a photochemical process for the manufacturing of a C-terminal α-amide, which are a class of compounds that represent up to half of all biologically relevant peptide hormones. The invention provides mild, broad in scope, economically efficient process, which is suitable for large scale manufacturing.[French] La présente invention concerne un procédé photochimique pour la production d'un alpha-amide C-terminal, lequel est une classe de composés qui représentent jusqu'à la moitié de toutes les hormones peptidiques biologiquement pertinentes. L'invention concerne un procédé doux, présentant une large portée et étant économiquement efficace, qui convient pour une fabrication à grande échelle.
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