WO2023094566 - LIBRARIES OF NUCLEIC ACIDS AND METHODS FOR OPTIMIZATION OF MRNA
National phase entry:
Publication Number
WO/2023/094566
Publication Date
01.06.2023
International Application No.
PCT/EP2022/083213
International Filing Date
24.11.2022
Title **
[English]
LIBRARIES OF NUCLEIC ACIDS AND METHODS FOR OPTIMIZATION OF MRNA
[French]
BANQUES D'ACIDES NUCLÉIQUES ET PROCÉDÉS D'OPTIMISATION DE L'ARNM
Applicants **
QUERDENKER APS
Skovvænget 32
5792 Årslev, DK
Inventors
MØLLER, Thorleif
Skovvænget 32
5792 Årslev, DK
Priority Data
PA202101118
24.11.2021
DK
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter II
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| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1075 | |
| EPO | Filing, Examination | 4598 | |
| Japan | Filing | 592 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 2710 |
Total: 9549 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention provides libraries of nucleic acids, wherein each nucleic acid specie of the libraries comprises a unique sequence of triplet codons encoding the same polypeptide and methods of using such libraries for identification of mRNA encoding specific polypeptides with improved characteristics e.g., with regards to improved chemical stability and improved biostability, while still allowing for efficient translation in target cells.[French]
La présente invention concerne des banques d'acides nucléiques, chaque espèce d'acide nucléique des bibliothèques comprenant une séquence unique de codons triplets codant pour le même polypeptide, ainsi que des procédés d'utilisation de telles banques pour l'identification d'ARNm codant pour des polypeptides spécifiques présentant des caractéristiques améliorées, par exemple, en ce qui concerne une stabilité chimique améliorée et une biostabilité améliorée, tout en permettant une traduction efficace dans des cellules cibles.