WO2023079032 - COMPOSITIONS AND METHODS FOR DETECTION OF MALARIA
National phase entry:
Publication Number
WO/2023/079032
Publication Date
11.05.2023
International Application No.
PCT/EP2022/080736
International Filing Date
03.11.2022
Title **
[English]
COMPOSITIONS AND METHODS FOR DETECTION OF MALARIA
[French]
COMPOSITIONS ET PROCÉDÉS POUR LA DÉTECTION DU PALUDISME
Applicants **
F. HOFFMANN-LA ROCHE AG
Grenzacherstrasse 124
4070 Basel, CH
ROCHE DIAGNOSTICS GMBH
Sandhofer Strasse 116
68305 Mannheim, DE
ROCHE MOLECULAR SYSTEMS, INC.
4300 Hacienda Drive
Pleasanton, California 94588, US
Inventors
CHIU, Sharon Ho-Chen
c/o Roche Molecular Systems, Inc.
4300 Hacienda Drive
Pleasanton, California 94588, US
GICHERU, Yvonne
c/o Roche Molecular Systems, Inc.
Hacienda Drive 4300
Pleasanton, California 94588, US
HEIL, Marintha
c/o Roche Molecular Systems, Inc.
Hacienda Drive 4300
Pleasanton, California 94588, US
LEE, Michael K.
c/o Roche Molecular Systems, Inc.
Pleasanton, California 94588, US
MANOHAR, Chitra
c/o Roche Molecular Systems, Inc.
Hacienda Drive 4300
Pleasanton, California 94588, US
ORDINARIO, Ellen
c/o Roche Molecular Systems, Inc.
4300 Hacienda Drive
Pleasanton, California 94588, US
RAJAMANI, Jaya
c/o Roche Molecular Systems, Inc.
4300 Hacienda Drive
Pleasanton, California 94588, US
SUN, Jingtao
c/o Roche Molecular Systems, Inc.
4300 Hacienda Drive
Pleasanton, California 94588, US
Priority Data
63/263,594
05.11.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1990 | |
| EPO | Filing, Examination | 12739 | |
| Japan | Filing | 590 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 9310 |
Total: 25204 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, primers and probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).[French]
Procédés pour la détection rapide de la présence ou de l'absence de parasites du paludisme (y compris le Plasmodium) dans un échantillon biologique ou non biologique. Les procédés peuvent comprendre la conduite d'une étape d'amplification, une étape d'hybridation, et une étape de détection. De plus, le dosage peut être un dosage multiplex, afin d'amplifier et de détecter simultanément une pluralité de cibles de Plasmodium, ce qui offre des avantages par comparaison aux dosages monoplex. En outre, la présente invention concerne des amorces oligonucléotidiques et des sondes oligonucléotidiques ciblant les parasites du paludisme (y compris le Plasmodium) et des kits conçus pour la détection du Plasmodium, y compris, mais sans s'y limiter, les espèces de Plasmodium suivantes : P. falciparum, P. vivax, P. ovale, P. knowlesi et P. malariae. La présente invention concerne également des kits, des mélanges réactionnels et des oligonucléotides (par exemple, amorce et sonde) pour l'amplification et la détection des parasites du paludisme (y compris le Plasmodium).