WO2023066834 - PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS

National phase entry:
Publication Number WO/2023/066834
Publication Date 27.04.2023
International Application No. PCT/EP2022/078767
International Filing Date 17.10.2022
Title **
[English] PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS
[French] DÉRIVÉS DE PYRROLIDINE EN TANT QU'INHIBITEURS DE DDR
Applicants **
CHIESI FARMACEUTICI S.P.A.
Inventors
CARZANIGA, Laura
RANCATI, Fabio
RIZZI, Andrea
GHIDINI, Eleonora
IOTTI, Nicolò
MAZZUCATO, Roberta
LEVANTO, Stefano
WHITTAKER, Ben Paul
Priority Data
21203367.4   19.10.2021   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2696
EPO Filing, Examination, Granting12367
Japan Filing, Examination, Granting2276
South Korea Filing, Examination, Granting2322
USA Filing, Examination, Granting5790
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Total: 25,451

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Abstract[English] The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.[French] La présente invention concerne des composés de formule (I) inhibant des récepteurs à domaine discoïdine (inhibiteurs de DDR), des procédés de préparation de tels composés, des composés intermédiaires utiles dans de telles préparations, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles, par exemple, dans le traitement de nombreux troubles associés à des mécanismes DDR.

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