WO2023062099 - FOCUSING DEVICE, FOCUSING SYSTEM, MICROSCOPE AND METHOD FOR IMAGING AND/OR LOCALIZING MOLECULES OR PARTICLES IN A SAMPLE
National phase entry:
Publication Number
WO/2023/062099
Publication Date
20.04.2023
International Application No.
PCT/EP2022/078441
International Filing Date
12.10.2022
Title **
[English]
FOCUSING DEVICE, FOCUSING SYSTEM, MICROSCOPE AND METHOD FOR IMAGING AND/OR LOCALIZING MOLECULES OR PARTICLES IN A SAMPLE
[French]
DISPOSITIF DE FOCALISATION, SYSTÈME DE FOCALISATION, MICROSCOPE ET PROCÉDÉ D'IMAGERIE ET/OU DE LOCALISATION DE MOLÉCULES OU DE PARTICULES DANS UN ÉCHANTILLON
Applicants **
ABBERIOR INSTRUMENTS GMBH
Hans-Adolf-Krebs-Weg 6
37077 Göttingen, DE
Inventors
HARKE, Benjamin
Stegemühlenweg 47
37083 Göttingen, DE
MITTELSTÄDT, Haugen
Lenglerner Straße 47
37120 Bovenden, DE
Priority Data
21202354.3
13.10.2021
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| * | |
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1138 | |
| EPO | Filing, Examination | 4709 | |
| Japan | Filing | 590 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 2710 |
Total: 9721 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The invention relates to a focusing device (1) for a microscope (100) comprising a first polarization switching element (3) configured to rotate a polarization of a linearly polarized light beam (L) around a first optical axis (A) from a first polarization direction (Pl) to a second polarization direction (P2) upon receiving a switching signal, and a focusing element (4) configured to axially displace a main focus (MF) of the light beam (L) generated by a microscope objective lens (121) between a first axial position and a second axial position dependent on the polarization of the light beam (L). The invention further relates to a focusing system (2) comprising at least two of the focusing devices (1), a microscope (100) using the focusing device (1) and a method for imaging and/or localizing molecules (M) or particles (P) in a sample (S).[French]
L'invention concerne un dispositif de focalisation (1) pour un microscope (100) comprenant un premier élément de commutation de polarisation (3) configuré pour faire tourner une polarisation d'un faisceau de lumière à polarisation linéaire (L) autour d'un premier axe optique (A) à partir d'une première direction de polarisation (Pl) à une seconde direction de polarisation (P2) lors de la réception d'un signal de commutation, et un élément de focalisation (4) configuré pour déplacer axialement un foyer principal (MF) du faisceau de lumière (L) généré par une lentille d'objectif de microscope (121) entre une première position axiale et une seconde position axiale en fonction de la polarisation du faisceau de lumière (L). L'invention concerne en outre un système de focalisation (2) comprenant au moins deux des dispositifs de focalisation (1), un microscope (100) utilisant le dispositif de focalisation (1) et un procédé d'imagerie et/ou de localisation de molécules (M) ou de particules (P) dans un échantillon (S).