WO2023006863 - NOVEL CRYSTALLINE FORMS OF [(1R)-2-(1-BENZOFURAN-3-YL)-1-{[(1S,2R,4R)-7- OXABICYCLO[2.2.1]HEPTAN-2-YL]FORMAMIDO}ETHYL]BORONIC ACID, ADDUCTS THEREOF, AND PROCESSES TO OBTAIN
National phase entry:
Publication Number
WO/2023/006863
Publication Date
02.02.2023
International Application No.
PCT/EP2022/071167
International Filing Date
28.07.2022
Title **
[English]
NOVEL CRYSTALLINE FORMS OF [(1R)-2-(1-BENZOFURAN-3-YL)-1-{[(1S,2R,4R)-7- OXABICYCLO[2.2.1]HEPTAN-2-YL]FORMAMIDO}ETHYL]BORONIC ACID, ADDUCTS THEREOF, AND PROCESSES TO OBTAIN
[French]
NOUVELLES FORMES CRISTALLINES D'ACIDE [(1R)-2-(1-BENZOFURAN-3-YL)-1-{[(1S,2R,4R)-7- OXABICYCLO[2.2.1]HEPTAN-2-YL]FORMAMIDO}ETHYL]BORONIQUE, PRODUITS D'ADDITION DE CEUX-CI, ET PROCÉDÉS D'OBTENTION CORRESPONDANTS
Applicants **
MERCK PATENT GMBH
Frankfurter Strasse 250
64293 Darmstadt, DE
Inventors
GRUIA, Delia-Maria
c/o Merck KGaA
Frankfurter Strasse 250
64293 DARMSTADT, DE
KLEIN, Markus
c/o Merck KGaA
Frankfurter Strasse 250
64293 DARMSTADT, DE
LANGE, Michael
c/o Merck KGaA
Frankfurter Strasse 250
64293 DARMSTADT, DE
Priority Data
63/226,986
29.07.2021
US
63/236,731
25.08.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Translation |
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Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1805 | |
| EPO | Filing, Examination | 9042 | |
| Japan | Filing | 591 | |
| South Korea | Filing | 607 | |
| USA | Filing, Examination | 7910 |
Total: 19955 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to a solid form of [(1R)-2-(1-benzofuran-3-yl)-1- {[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, hydrates, solvates, and/or adducts thereof useful as LMP7 inhibitors.[French]
La présente invention concerne une forme solide d'acide [(1R)-2-(1-benzofuran-3-yl)-1- {[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronique, des hydrates, des solvates et/ou des produits d'addition de ceux-ci utiles en tant qu'inhibiteurs de LMP7.