WO2023011750 - FORMULATION FOR SUBSTITUTED 2-AMINOTHIAZOLES IN THE TREATMENT OF FUNGAL AND FUNGAL-BACTERIAL INFECTIONS OF THE NAIL
National phase entry:
Publication Number
WO/2023/011750
Publication Date
09.02.2023
International Application No.
PCT/EP2022/000073
International Filing Date
03.08.2022
Title **
[English]
FORMULATION FOR SUBSTITUTED 2-AMINOTHIAZOLES IN THE TREATMENT OF FUNGAL AND FUNGAL-BACTERIAL INFECTIONS OF THE NAIL
[French]
FORMULATION DE 2-AMINOTHIAZOLES SUBSTITUÉS DANS LE TRAITEMENT DES INFECTIONS FONGIQUES ET FONGO-BACTÉRIENNES DE L'ONGLE
Applicants **
ONYCHOPHARM GMBH
Am Borsigturm 100
130507 Berlin, DE
EPINAMICS GMBH
Wachtelstr. 15
14195 Berlin, DE
Inventors
BREMBECK, Felix
Kurfürstenstr. 126 A
10785 Berlin, DE
BAASNER, Bernd
Wagnerstr. 83
51467 Bergisch Gladbach, DE
FUGMANN, Burkhard
Dr.-Kessel-Str. 3
40878 Ratingen, DE
THIEDE, Hans-Michael
Hermannswerder 14
14773 Potsdam, DE
KEHR, Wolfgang
Wachtelstrasse 15
14195 Berlin, DE
Priority Data
21000212.7
04.08.2021
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1200 | |
| EPO | Filing, Examination | 4881 | |
| Japan | Filing | 595 | |
| South Korea | Filing | 574 | |
| USA | Filing, Examination | 3310 |
Total: 10560 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
A formulation for substituted 2-aminothiazoles in the prophylaxis and treatment of fungal and fungal-bacterial infections of the nail (onychomycosis) is disclosed. These formulations are particularly suitable for the topical application onto a nail. After evaporation of the solvent a thin polymer layer is formed on the nail from which the substituted 2-aminothiazole diffuses into the nail and the nail bed. A particularly effective substituted 2-aminothiazole is abafungin. The substituted 2-aminothiazoles are not only fungicidal, but also sporicidal and anti-bacterial. This is a novel approach to efficiently treat onychomycosis and to avoid frequent relapses of the infection.[French]
L'invention concerne une formulation de 2-aminothiazoles substitués dans la prophylaxie et le traitement des infections fongiques et fongo-bactériennes de l'ongle (onychomycose). Ces formulations sont particulièrement adaptées à l'application topique sur un ongle. Après évaporation du solvant, une fine couche de polymère se forme sur l'ongle, à partir de laquelle le 2-aminothiazole substitué diffuse dans l'ongle et le lit de l'ongle. Un 2-aminothiazole substitué particulièrement efficace est l'abafungine. Les 2-aminothiazoles substitués sont non seulement fongicides, mais aussi sporicides et antibactériens. Il s'agit d'une nouvelle approche pour traiter efficacement l'onychomycose et éviter les rechutes fréquentes de l'infection.