WO2022090448 - NOVEL ACYLATING REAGENTS
National phase entry is expected:
Publication Number
WO/2022/090448
Publication Date
05.05.2022
International Application No.
PCT/EP2021/080091
International Filing Date
29.10.2021
Title **
[English]
NOVEL ACYLATING REAGENTS
[French]
NOUVEAUX RÉACTIFS D'ACYLATION
Applicants **
NOVO NORDISK A/S
Novo Allé
2880 Bagsværd, DK
Inventors
JENSEN, Kim, Birkebæk
Novo Allé
2880 Bagsværd, DK
MIKKELSEN, Jesper, Hyldal
Novo Allé
2880 Bagsværd, DK
Priority Data
20204843.5
30.10.2020
EP
21191948.5
18.08.2021
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| * | |
International Searching Authority |
EPO
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter II
* |
| * | |
| * | |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1455 | |
| EPO | Filing, Examination | 5374 | |
| Japan | Filing | 590 | |
| South Korea | Filing | 607 | |
| USA | Filing, Examination | 2710 |
Total: 10736 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention relates to a novel acylating reagent, a method for its preparation, and a method of using it for acylating at the N-terminal of a peptide or a protein. The novel acylating reagent may be a compound which comprises 5-bromo-2-hydroxy-N,N-dimethyl-3-(trifluromethyl)benzenesulfonamide or 5-bromo-2-hydroxy-3-(trifluromethyl)benzenesulfonic acid. This novel acylating reagent enables acylation at the B1 position of insulin.[French]
La présente invention concerne un nouveau réactif d'acylation, un procédé pour sa préparation, et un procédé d'utilisation de celui-ci pour l'acylation au niveau de la terminaison N d'un peptide ou d'une protéine. Le nouveau réactif d'acylation peut être un composé qui comprend du 5-bromo-2-hydroxy-N, N-diméthyl-3-(triflurométhyle)benzènesulfonamide ou de l'acide 5-bromo-2-hydroxy-3-(triflurométhyl)benzènesulfonique. Ce nouveau réactif d'acylation permet l'acylation au niveau de la position B1 de l'insuline.