WO2022090448 - NOVEL ACYLATING REAGENTS
National phase entry is expected:
Publication Number
WO/2022/090448
Publication Date
05.05.2022
International Application No.
PCT/EP2021/080091
International Filing Date
29.10.2021
Title **
[English]
NOVEL ACYLATING REAGENTS
[French]
NOUVEAUX RÉACTIFS D'ACYLATION
Applicants **
NOVO NORDISK A/S
Inventors
JENSEN, Kim, Birkebæk
MIKKELSEN, Jesper, Hyldal
Priority Data
20204843.5
30.10.2020
EP
21191948.5
18.08.2021
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter II
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2402 | |
| EPO | Filing, Examination, Granting | 9747 | |
| Japan | Filing, Examination, Granting | 2247 | |
| South Korea | Filing, Examination, Granting | 2229 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
21,365
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to a novel acylating reagent, a method for its preparation, and a method of using it for acylating at the N-terminal of a peptide or a protein. The novel acylating reagent may be a compound which comprises 5-bromo-2-hydroxy-N,N-dimethyl-3-(trifluromethyl)benzenesulfonamide or 5-bromo-2-hydroxy-3-(trifluromethyl)benzenesulfonic acid. This novel acylating reagent enables acylation at the B1 position of insulin.[French]
La présente invention concerne un nouveau réactif d'acylation, un procédé pour sa préparation, et un procédé d'utilisation de celui-ci pour l'acylation au niveau de la terminaison N d'un peptide ou d'une protéine. Le nouveau réactif d'acylation peut être un composé qui comprend du 5-bromo-2-hydroxy-N, N-diméthyl-3-(triflurométhyle)benzènesulfonamide ou de l'acide 5-bromo-2-hydroxy-3-(triflurométhyl)benzènesulfonique. Ce nouveau réactif d'acylation permet l'acylation au niveau de la position B1 de l'insuline.