WO2023030667 - PROCESS FOR THE PREPARATION OF CHLOROALKYL SUBSTITUTED CYCLIC AMINES
National phase entry:
Publication Number
WO/2023/030667
Publication Date
09.03.2023
International Application No.
PCT/EP2021/075830
International Filing Date
20.09.2021
Title **
[English]
PROCESS FOR THE PREPARATION OF CHLOROALKYL SUBSTITUTED CYCLIC AMINES
[French]
PROCÉDÉ DE PRÉPARATION D'AMINES CYCLIQUES À SUBSTITUTION CHLOROALKYLE
Applicants **
HOVIONE FARMACIENCIA SA
Sete Casas
2674-506 Loures, PT
TURNER, Craig
Octagon Point 5 Cheapside
London EC2V 6AA, GB
Inventors
KATZ, Marianna
Rua Rafael Duque nº21, 3ºDto
1500-249 Lisboa, PT
TORRES, Nuno
Estrada da Ameixoeira nº31, 3º Esq.
1750-014 Lisboa, PT
SOBRAL, Luis
Rua Gazeta do Sul 43, 4º Dto
2870-826 Montijo, PT
ANTUNES, Rafael
Rua Engº Henrique Cabeçadas 31, 3º Dto
2900-005 Setubal, PT
Priority Data
117440
03.09.2021
PT
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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International Searching Authority |
EPO
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter II
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| * | |
| * | |
| Translation |
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Recalculate
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1423 | |
| EPO | Filing, Examination | 6819 | |
| Japan | Filing | 589 | |
| South Korea | Filing | 575 | |
| USA | Filing, Examination | 2710 |
Total: 12116 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
A process for the preparation of a compound of formula (II) where Et = ethyl; Bn = benzyl and Ph = phenyl; comprises the step of reacting a cyclic amine with an alkylating agent to form a compound of formula II, wherein the process is solvent-free.The chloroalkyl N-substituted cyclic amines of formula II may be used in the preparation of active pharmaceutical ingredients or intermediates therefor comprising these moieties in their molecular structure.[French]
Un procédé de préparation d'un composé de formule (II) où Et = éthyle ; Bn = benzyle et Ph = phényle ; comprend l'étape consistant à faire réagir une amine cyclique avec un agent alkylant pour former un composé de formule II, le procédé étant exempt de solvant. Les amines cycliques N-substituées de chloroalkyle de formule II peuvent être utilisées dans la préparation d'ingrédients pharmaceutiques actifs ou d'intermédiaires associés comprenant ces fractions dans leur structure moléculaire.