WO2026145382 - COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF COMPLEMENT FACTOR B (CFB)

National phase entry is expected:
Publication Number WO/2026/145382
Publication Date 09.07.2026
International Application No. PCT/CN2025/146432
International Filing Date 29.12.2025
Title **
[English] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF COMPLEMENT FACTOR B (CFB)
[French] COMPOSITIONS ET PROCÉDÉS POUR INHIBER L'EXPRESSION DU FACTEUR B DU COMPLÉMENT (CFB)
Applicants **
SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD.
Inventors
SHU, Dongxu
SHAO, Pengcheng Patrick
Priority Data
PCT/CN2024/143605   30.12.2024   CN
PCT/CN2025/082044   12.03.2025   CN
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting4429
EPO Filing, Examination, Granting68235
Japan Filing, Examination, Granting4184
South Korea Filing, Examination, Granting6570
USA Filing, Examination, Granting19590
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Total: 103,008
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Abstract[English] Compositions and methods useful to reduce expression of CFB gene and for treatment of CFB-associated diseases and conditions are provided. Provided are CFB dsRNA agents, CFB antisense polynucleotide agents, compositions comprising CFB dsRNA agents, and compositions comprising CFB antisense polynucleotide agents that can be used to reduce CFB expression in cells and subjects.[French] L'invention concerne des compositions et des procédés utiles pour réduire l'expression du gène CFB et pour le traitement de maladies et d'états associés à CFB. L'invention concerne des agents d'ARNdb CFB, des agents polynucléotidiques antisens CFB, des compositions comprenant des agents d'ARNdb CFB, et des compositions comprenant des agents polynucléotidiques antisens CFB qui peuvent être utilisés pour réduire l'expression de CFB dans des cellules et des sujets.