WO2026130508 - COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE(HMGCR)
National phase entry is expected:
Publication Number
WO/2026/130508
Publication Date
25.06.2026
International Application No.
PCT/CN2025/143801
International Filing Date
19.12.2025
Title **
[English]
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE(HMGCR)
[French]
COMPOSITIONS ET MÉTHODES POUR INHIBER L'EXPRESSION DE LA 3-HYDROXY-3-MÉTHYLGLUTARYL-COA RÉDUCTASE (HMGCR)
Applicants **
SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD.
Inventors
SHU, Dongxu
SHAO, Pengcheng Patrick
LU, Mingjian
Priority Data
PCT/CN2024/141253
21.12.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4955 | |
| EPO | Filing, Examination, Granting | 72928 | |
| Japan | Filing, Examination, Granting | 4244 | |
| South Korea | Filing, Examination, Granting | 6674 | |
| USA | Filing, Examination, Granting | 23290 |
Total:
112,091
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Abstract[English]
Compositions and methods useful to reduce expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene and for treatment of HMGCR-associated diseases and conditions are provided. Provided are HMGCR dsRNA agents, HMGCR antisense polynucleotide agents, compositions comprising HMGCR dsRNA agents, and compositions comprising HMGCR antisense polynucleotide agents that can be used to reduce HMGCR expression in cells and subjects.[French]
Des compositions et des méthodes utiles pour réduire l'expression du gène de la 3-hydroxy-3-méthylglutaryl-CoA réductase (HMGCR) et pour le traitement de maladies et d'affections associées à HMGCR sont fournies. Sont fournis des agents ARNdb ciblant HMGCR, des agents polynucléotidiques antisens ciblant HMGCR, des compositions comprenant des agents ARNdb ciblant HMGCR, et des compositions comprenant des agents polynucléotidiques antisens ciblant HMGCR, pouvant être utilisés pour réduire l'expression de HMGCR dans des cellules et chez des sujets.